Current federal animal use legislation emphasizes the need for the minimization of pain or distress imposed on animals during the course of a research study. The methods used to prevent, relieve, or minimize this pain or distress must be stated by the principal investigator. Also, any animal use causing pain or distress, which cannot be relieved by anesthetics, analgesics, tranquilizers, or sedatives must be justified for scientific reasons by the principal investigator in the animal study proposal. All efforts should be made to find alternatives to these procedures and avoid using these procedures, unless absolutely necessary for the outcome of the study. For guidance contact the Lab Animal Sciences Program - Bethesda at 301-496-1866.
The following procedures and techniques may cause significant pain or distress:
Other procedures that may cause significant pain and/or distress:
The following procedures or techniques when performed properly by skilled personnel are not considered painful or distressful, but certain standards should be followed when these procedures are undertaken (For guidance contact the Lab Animal Sciences Program-Bethesda at 301-496-1866):