Strain Code 01116 [29S1/SvImJ/Cr]
Origin and Characteristics
Received by NCI from Jackson Laboratory in 2002. Historically, the 129 inbred mice
are known for the high incidence of spontaneous testicular teratomas, though the
incidence differs between substrains. In response to challenge, 129S1/SvImJ mice
develop immune-mediated nephritis characterized by proteinuria, glomerulonephritis
and tubulointerstitial disease (Xie et al., 2004). Most recently 129 mice are a
widely used strain in the production of targeted mutations due to the availability
of several lines of embryonic stem cells.