Strain Code 01D35 [DBA/2NCr] (Dilute brown, dba, dba-2, dba subline 212, DBA.2JN)
Origin and Characteristics
To N 1951 from Mider at F34. See DBA/1N for origin of DBA/1 and DBA/2 strains, but
to Mider in 1938.
Genetics
a, b, d, C
Non-agouti, dulite brown
Genes:
Car-2b, Ce-2a, Es-1b, Es-3c, Es-10b,
Gpd-1b, Gpi-1a, Gusb, Hbag, Hbbd,
Idh-1b, Lva, Mod-1a, Mup-1a, Pep-3b,
Pgm-1b, Trfb
Hc0, H-2Dd, H-2Kd, Lyb-2a, Lyt-1a,
Lyt-2a, Lyt-3b, Thy-1b, Tlac.
Diseases
Neoplastic (Spontaneous)
- Mammary tumors in old females. (680)
Neoplastic (Induced)
- 3-Methylcholanthrene induced brain tumors in only 3%. (404)
- In comparison with other inbred strains, DBA/2 is susceptible to Bittner, Friend
S and Friend B viruses, relatively susceptible to Gross virus, and resistant to
Vaccinia virus. (370)
- Benzo(a)pyrene induced more fibrosarcomas in C3H mice than in DBA/2 mice, and simultaneous
application of 7, 8-benzoflavone caused a greater increase in tumor incidence in
C3H mice; however, 1, 1, 1-trichloropropene-2, 3-oxide plus benzo(a)pyrene induced
a higher incidence of fibrosarcomas in DBA/2 mice. (781)
Non-Neoplastic (Spontaneous)
- Intestinal volvulus in a small percentage. (140)
- Over 50% of males and females had dystrophic cardiac calcinosis in the myocardium
and/or epicardium. (160)
Non-Neoplastic (Induced)
- Relatively resistant to infection by Plasmodium berghei. (492)
- Susceptible to infection with Leishmania tropica, but no clinical signs
of disease. (063)
Other Characteristics
Immunologic
- High interferon induction by Newcastle disease virus. (696)
- Antibody response to single-stranded DNA is low and response is controlled by an
autosomal dominant gene regulated by sex hormones. (571)
Biochemical
- Aryl hydrocarbon hydroxylase increased only 20% by 3-methylcholanthrene. The “nonresponsive”
Ahd allele is present. (404,403)
- Gamma-aminobutyric acid binding was lower in DBA/2 than C57BL/6 cerebral cortex,
hippocampus, striatum, and diencephalons. (739)
- Liver alcohol dehydrogenase activity is slightly lower, and liver alhehyde dehydrogenase
much lower than C57BL/6. (299)
- Morphine decreased acetylcholine turnover rate in cerebral cortex. (561)
Physiologic
- Low plasma resting steroid levels, peak only briefly after stress. (398)
Behavioral
- Quickly develops an aversion to ethanol. (299)
Misc.
- Susceptible to audiogenic seizures; susceptibility begins at 12-17 days, peaks at
21 days, then gradually declines with age. (646)
- Antithyroid drugs or radiothyroidectomy suppresses susceptibility to audiogenic
seizures. Suitable as a model for testing anticonvulsants. (647, 421)
- Oral benzo(a)pyrene killed mice in 4 weeks due to pancytopenia. (737)
- 3-Methylcholanthrene was less toxic to DBA/2N primordial oocytes than to C57BL/6N
oocytes. (447)
- More sensitive to toxic effects of chloroform than C57BL/6. (097)
- More sensitive to analgesic action of morphine than C57BL/6. (561)