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• Strain Code 01F50

Strain Code 01F50 [FVB/NCr]

Origin and Characteristics

In 1966, outbred Swiss mice at the National Institutes of Health were selectively bred for either resistance or sensitivity to histamine challenge post pertussis vaccination. In 1975 by continuous sib-matings of a group of animals separated from HSFS/N at about F8 was found to carry the Fv1b allele which confers sensitivity to the Friend leukemia virus B strain. The FVB/N strain resulted from inbreeding this line for the Fv1^b allele. Due to the prominent pronuclei in their fertilized eggs and the large litter size, FVB/NJ mice are commonly used for transgenic injection.

Genetics

Genes:

Car-2^b, Ce-2^a, Es-1^b, Es-3^c, Es-10^a, Gpd-1^b, Gpi-1^b, Gus^b, Hbb^d, Idh-1^a, Mod-1^a, Mup-1^c, Pep-3^b, Pgm-1^a, Trf^b
Hc¹, Lyt-1^b, Thy-1^a.

Other Characteristics

• Carries Fv-1^b.