Strain Code 01S11 [SCID/NCr - BALB/C background]
Origin and Characteristics
SCID mice possess a genetic autosomal recessive mutation (scid). Discovered in 1980 by Bosma in C.B-17/Icr mice at Fox Chase Cancer Center. SCID mice show a severe combined immunodeficiency affecting both B and T lymphocytes. They have normal NK cells, macrophages, and granulocytes. NCI received this mouse in 1991.