Monomeric CH3: A Small, Stable Antibody Domain with Therapeutic Promise

Two men talking by the computer

Tianlei Ying, Ph.D. (facing camera), postdoctoral fellow, and Dimiter Dimitrov, Ph.D., head, Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research.

By Ashley DeVine, Staff WriterPlatinum Highlight Icon

Antibody domains are emerging as promising biopharmaceuticals because of their relatively small size compared to full-sized antibodies, which are too large to effectively penetrate tumors and bind to sterically restricted therapeutic targets.

In an article published in The Journal of Biological Chemistry, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Protein Interactions Group, Cancer and Inflammation Program, Center for Cancer Research, reported their design of a novel antibody domain, monomeric CH3 (mCH3).

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More than 3,200 Books and DVDs Donated to Annual Book Swap

People searching through books

Robin Meckley, Contributing Writer

The Scientific Library’s 14th Annual Book and Media Swap, held on April 16 in the lobby of Building 549, proved to be a popular event.

When the swap was rescheduled from fall 2013 to spring 2014, the library staff was uncertain if the response would be equal to previous years, said Sue Wilson, principal manager of the Scientific Library. NCI at Frederick employees rose to the challenge, however, with 87 people donating more than 3,200 books and DVDs, according to Pam Noble, serials technician and book swap team leader. By the end of the first day of the swap, almost half of the materials had been claimed.

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Weather Advisory: Tornados

Tornado graphic

Summer months carry the threat of severe storms and tornados in our area. Take a few moments to consider how well you are prepared in the event of a tornado warning.

The time to prepare for a tornado is before it happens. The Federal Emergency Management Agency (FEMA) provides information on how to prepare and what to do in the event of a tornado. Take a few moments to read the important safety information FEMA has assembled: http://www.ready.gov/tornadoes.

Sign Up for Text Alerts from Frederick County

You can also sign up for text alerts to your cell phone from Frederick County at http://www.frederickcountymd.gov/ALERT.

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New Animal Model Could Boost Research on AIDS Drugs and Vaccines

Monkeys with cells illustration

The figure shows the serial passage of minimally changed HIV into a series of pigtail macaques to adapt the virus, which became capable of causing AIDS in the monkeys, beginning after the third animal-to-animal passage (“P4” in the figure). Inverted monkey icons indicate animals that succumbed to AIDS-defining conditions. The background demonstrates depletion of CD4+ T cells from gut-associated lymphoid tissues, a hallmark of AIDS virus pathogenesis.

By Frank Blanchard, Staff Writer, and Jeff Lifson, Guest Writer

In a research milestone reported in the June 20 issue of the journal Science, scientists have developed a minimally modified version of HIV-1, the virus that causes AIDS in infected humans, that is capable of causing progressive infection and AIDS in monkeys. The advance should help create more authentic animal models of the disease and provide a potentially invaluable approach for faster and better preclinical evaluation of new drugs and vaccines.

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New Hires at the National Cancer Institute at Frederick

NCI, Leidos and DMS logos.

Fifty-six people joined the facility in January, February, and March 2014.

The National Cancer Institute welcomes…

Shailesh Ambre • Lucia Babini • Hideaki Bando • Sandip Basu • Konstantinos Dimas • Amber Elia • Lan Jin • Yifei Li • Hanhan Liu • Hugo Martinez • Manasi Mayekar • Michele Newton • Sheikh Rahman • Luis Rodriguez • Eric Sterner • Emmanuel Tavares • Yanping Wang • Sarah Watters

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NCI Researchers Discover Exceptionally Potent Antibodies with Potential for Prophylaxis and Therapy of MERS-Coronavirus Infections

Crystal structures.

Docked complexes of MERS-CoV RBD with mAbs (A) m336, (B) m337, and (C) m338. (D) Superposition of the docked complexes of RBD-m336,7,8 and the crystal structure of the RBD-DPP4 complex.

By Andrea Frydl, Contributing Writer

In a recent article published in the Journal of Virology, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Laboratory of Experimental Immunology (LEI), Cancer and Inflammation Program, NCI Center for Cancer Research, reported the identification of three human monoclonal antibodies (m336, m337, and m338) that target the part of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) that is responsible for binding to its receptor. These antibodies are exceptionally potent inhibitors of MERS-CoV infection and also provide a basis for creating a future MERS-CoV vaccine.

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