NCI Researchers Discover Exceptionally Potent Antibodies with Potential for Prophylaxis and Therapy of MERS-Coronavirus Infections

Crystal structures.

Docked complexes of MERS-CoV RBD with mAbs (A) m336, (B) m337, and (C) m338. (D) Superposition of the docked complexes of RBD-m336,7,8 and the crystal structure of the RBD-DPP4 complex.

By Andrea Frydl, Contributing Writer

In a recent article published in the Journal of Virology, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Laboratory of Experimental Immunology (LEI), Cancer and Inflammation Program, NCI Center for Cancer Research, reported the identification of three human monoclonal antibodies (m336, m337, and m338) that target the part of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) that is responsible for binding to its receptor. These antibodies are exceptionally potent inhibitors of MERS-CoV infection and also provide a basis for creating a future MERS-CoV vaccine.

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How You Can Help Save a Life

Man donating blood.

Kevin Zecher, a regular double-red donor, gives his red blood cells during the Red Cross Blood Drive held at NCI at Frederick on April 10. OHS regularly hosts blood drives for both whole blood and double-red cell donations.

By Carolynne Keenan, Contributing Writer

Kevin Zecher, a maintenance mechanic in Facilities Maintenance and Engineering, Leidos Biomedical Research, Inc., hasn’t missed a double-red cell donation at a blood drive at NCI at Frederick in four years.

He marks the time by his first granddaughter’s birth—that’s when he first decided to donate more than whole blood.

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Susan Koogle Marks 40+ Years at NCI at Frederick

Studio portrait of Susan Koogle

Susan Koogle, Computer Operator IV, Data Management Services

By Nancy Parrish, Staff Writer

In 1973, Susan Koogle commuted from Washington County to a small data processing company in Arlington, Va. When gas prices spiked from 25 to 54 cents a gallon, she began to look for a job closer to home. That’s when she came to work at NCI at Frederick, and in December 2013, she marked her 40th year with the facility.

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Platinum Publications – As of April 30, 2014

Platinum Publications graphic

Platinum Publications are selected from articles by NCI at Frederick scientists published in 21 prestigious science journals. This list represents new publications generated from PubMed as of the date shown above.

Articles designated as Platinum Highlights are noteworthy articles selected by Dr. Craig Reynolds, associate director, National Cancer Institute, from among the most recently published Platinum Publications.

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(Updated) Students, Teachers Share Technology Now Advantages with ATRF Staff

students having a discussion

Philip Evich, a senior at Middletown High School, explains the advantages of using technology to enrich his Advanced Placement Literature class. Evich and his classmates run a literature blog enabling them to discuss the books read in class, as well as comment on each other’s theories, all online. 

By Carolynne Keenan, Contributing Writer

Philip Evich, a senior at Middletown High School, loves talking about literature, even beyond the allotted 90 minutes of his Advanced Placement (AP) Literature class. That’s why he and his classmates embraced the opportunity to blog about books read in the class.

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OHS Encouraged Employees to “Take a Hike” Twice in April

Four people walking down the street.

Employees brave the cooler weather on April 2 to walk the 1.3-mile course around Fort Detrick during Take a Hike Day.

By Carolynne Keenan, Contributing Writer

The chilly weather didn’t dampen the spirits of Take a Hike Day participants on Wednesday, April 2. Over 50 employees braved cool, misty weather to walk or jog around Fort Detrick during their lunch hours.

“The Take a Hike Day is [a way] to encourage everyone to get up and get moving,” said Sarah Hooper, RN, manager of Occupational Health Services (OHS). “OHS and the R&W partnered to encourage employees to engage in physical activity to improve their health.”

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