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Scientists Discover New Possibilities at Scientific Investigators Retreat

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Jim Cherry, Ph.D. (center), tries out the Oculus Rift device, which is being used by ABCC to develop virtual research capabilities. Assisting him (from left) are Raul Cachau, Ph.D., and Yanling Liu, Ph.D., ABCC. 

By Nancy Parrish, Staff Writer; photos by Richard Frederickson, Staff Photographer

Scientists who attended the 2015 NCI Intramural Scientific Investigators Retreat on Jan. 13 had a chance to discuss research results with other investigators from across the National Cancer Institute. And this year, they could also explore new possibilities for the future of their research.

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Experimental Lung Cancer Drug Shows Early Promise

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By Frank Blanchard, Staff Writer

A first-of-its-kind drug is showing early promise in attacking certain lung cancers that are hard to treat because they build up resistance to conventional chemotherapy.

The drug, CO-1686, performed well in a preclinical study involving xenograft and transgenic mice, as reported in the journal Cancer Discovery. It is now being evaluated for safety and efficacy in Phase I and II clinical trials.

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How Asking a Very Basic Research Question Led Us to a Model for at Least Three Diseases

Portrait of Howard Young

By Howard Young

Editor’s note: This article is adapted from Dr. Young’s January 12, 2015, post to the I am Intramural Blog of the Intramural Research Program.

When I started this project, it was not my objective to develop a model for any specific disease, nor did I even suspect that the ultimate result would be some insight into autoimmune disease. The basic research question I was asking was why there are sequences in the 3′ untranslated region (3′UTR) of the interferon-gamma (IFN-gamma) mRNA that are more highly conserved than in the coding region of the gene.

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NCI Scientists Awarded National Medal of Technology and Innovation by President Obama

Schiller, Lowy, President Obama, and military aide holding medal at ceremony.

John Schiller, Ph.D., left, and Douglas Lowy, M.D., stand with President Obama to receive the National Medal of Technology and Innovation award at a White House ceremony in November. Photo reproduced from Whitehouse.gov.

Two NCI scientists received the National Medal of Technology and Innovation, the nation’s highest honor for technological achievement. The award was announced by President Obama in October. The honorees, John Schiller, Ph.D., Laboratory of Cellular Oncology (LCO), Center for Cancer Research, NCI, and Douglas Lowy, M.D., also from LCO and NCI deputy director, received their medals at a White House ceremony on Nov. 20.

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