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NCI Researchers Discover Exceptionally Potent Antibodies with Potential for Prophylaxis and Therapy of MERS-Coronavirus Infections

Crystal structures.

Docked complexes of MERS-CoV RBD with mAbs (A) m336, (B) m337, and (C) m338. (D) Superposition of the docked complexes of RBD-m336,7,8 and the crystal structure of the RBD-DPP4 complex.

By Andrea Frydl, Contributing Writer

In a recent article published in the Journal of Virology, Tianlei Ying, Ph.D., Dimiter Dimitrov, Ph.D., and their colleagues in the Laboratory of Experimental Immunology (LEI), Cancer and Inflammation Program, NCI Center for Cancer Research, reported the identification of three human monoclonal antibodies (m336, m337, and m338) that target the part of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) that is responsible for binding to its receptor. These antibodies are exceptionally potent inhibitors of MERS-CoV infection and also provide a basis for creating a future MERS-CoV vaccine.

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Second Annual David Derse Memorial Lecture and Award

Three people with an award.

Second Annual David Derse Memorial Lecture and Award. From left: Hye Kyung Chung-Derse, Ph.D.; Chou-Zen Giam, Ph.D.; and Stephen Hughes, Ph.D., director, HIV Drug Resistance Program. 

By Anne Arthur, Guest Writer

The Second Annual David Derse Memorial Lecture and Award presentation was held on November 12, 2013, at the NCI at Frederick Conference Center to honor David Derse’s outstanding research accomplishments and to stimulate the exchange of innovative ideas that Derse was well known for promoting throughout his scientific career.

The Annual David Derse Memorial Lecture and Award is sponsored by the HIV Drug Resistance Program, with support from Hye Kyung Chung-Derse, Ph.D., the National Cancer Institute (NCI), the Foundation for the National Institutes of Health (NIH), and colleagues and friends of Derse who contributed to the memorial fund in his honor.

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Investigators Retreat: A Forum to Bridge Frederick and Bethesda Cancer Research

The Ronald Reagan Building

The atrium of the Ronald Reagan Building has a ceiling height of up to 125 feet

By Andrea Frydl, Contributing Writer

Nearly 700 researchers, scientists, and laboratory technicians convened in the Ronald Reagan Building and International Trade Center in Washington, DC, for the 2014 NCI Intramural Scientific Investigators Retreat on Jan. 14.

The event featured presentations and posters exploring topics in cancer research from KRAS signaling to animal care.

One of the highlights of the event was a presentation made by Valerie Beral, Ph.D., from University of Oxford, discussing “Rosalind Franklin and Cancer in Women.” 

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