Science

BDP Is Unified at the ATRF

A man attaches a valve to a tank..

Mark Slatcoff attaches a sample valve to the 1,000-liter bioreactor, which is used for large-scale cell culture production. After production, the material is filtered or centrifuged, and then further processed before the final bulk product is produced. The final bulk product is filtered again, and then vialed for use in preclinical or clinical trials.

By Ken Michaels, Staff Writer

The Biopharmaceutical Development Program (BDP) at the Frederick National Laboratory is, for the first time ever, in a single building at the Advanced Technology Research Facility (ATRF).

At Fort Detrick, BDP operations were spread out in about a dozen buildings, resulting in redundancies in maintaining various utilities (air handlers, clean steam, WFI, etc.) for multiple buildings rather than one.

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Protein Laboratories in Single Location

Two men in a laboratory.

LPAT researchers Ming Zhou (left) and Athar Masood set up equipment in the new mass spectrometry laboratory at the ATRF.

By Andrew Stephen, Timothy Veenstra, and Gordon Whiteley, Guest Writers, and Ken Michaels, Staff Writer

The Laboratory of Proteomics and Analytical Technologies (LPAT), Antibody Characterization Laboratory (ACL), and Protein Chemistry Laboratory (PCL), previously located on different floors or in different buildings, are now together on the first floor of C wing in the ATRF.

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PEL Staff Together for the First Time

Man working with instruments

Troy Taylor adjusts the steam pressure on the manifold that provides pharmaceutical air, chilled water, steam, oxygen, and other gases to the bioreactors in PEL’s fermentation laboratory.

By Ashley DeVine, Staff Writer

John-Paul Denson and Troy Taylor of the Protein Expression Laboratory (PEL) used to pack liters of Escherichia coli lysates on ice, put them in the back of a microvan, and drive across campus to deliver the samples for protein purification.

Now that all PEL staff members are working under the same roof at the Advanced Technology Research Facility (ATRF), transferring samples is just a walk down the hall. Staff members were previously spread out in five buildings across the Fort Detrick campus.

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Genetics Research Discovered in a Bestseller

man holding book and aritcle.

Amar Klar holds the novel in which his research on yeast genetics was accurately described by the author, who is not a scientist and has never even met Klar. In his right hand, Klar holds a photo of himself that was taken in 1979 at Cold Spring Harbor Laboratory, where he performed the research.

By Nancy Parrish, Staff Writer

One morning in early January, Amar Klar sat down at his computer and found an e-mail with a curious message from a colleague.

While reading a bestselling novel, The Marriage Plot by Jeffrey Eugenides, his colleague, a professor at Princeton University, found a description of research on yeast genetics that was surprisingly similar to Klar’s early research. Even the laboratory in the novel was reminiscent of Cold Spring Harbor Laboratory, where Klar had conducted his research.

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