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National Cancer Institute's Nanotechnology Characterization Lab "Lessons Learned" Workshop 2013

September 20, 2013
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Spacer National Cancer Institute's Nanotechnology Characterization Lab "Lessons Learned" Workshop 2013 - Agenda

Agenda Information

NCI's Nanotechnology Characterization Lab (NCL) is providing an intensive one-day workshop on the science of preclinical characterization of nanomaterials. This workshop will cover some of the "lessons learned" from the NCL's testing of more than 280 nanotechnology-based candidate cancer treatments and diagnostics. The NCL performs physiochemical characterization, in vitro experiments and in vivo testing for collaborators, to support regulatory filings with the FDA.

The morning session will cover methods for nanomaterial characterization, including strategies for determining appropriate tests for batch-to-batch consistency, surface characterization, etc., nanomaterial ADME/Tox and PK, sterility and endotoxin contamination, immunotoxicity, and linking physicochemical characterization to safety and efficacy. This session will highlight methods from the NCL's three-phase Assay Cascade.

The afternoon will be devoted to case studies from NCL preclinical characterization, with details on specific nanomaterials, issues/problems encountered during NCL testing (e.g. impurities, agglomeration, unexpected toxicities, immune reactions, etc.), and how these were overcome.

Featuring sessions by:

  • Scott McNeil, NCL Director
  • Anil Patri, NCL Chemist
  • Stephan Stern, NCL Toxicologist
  • Marina Dobrovolskaia, NCL Immunologist
  • Jeff Clogston, NCL Chemist

More information about the NCL is available at http://ncl.cancer.gov.


Agenda - Friday, September 20th, 2013

9:00-9:30am Opening Remarks - Scott McNeil
9:30-10:15am Physiochemical Characterization - Anil Patri
10:15-10:30am Break
10:30-11:15am Nanotox and Pharmacology - Steve Stern
11:15-12:00pm Nanoimmunology - Marina Dobrovolskaia
12:00-1:00pm Lunch Break
1:00-3:00pm Focus Topics: e.g., Sterility, Autophagy, Light Scattering, Microscopy - NCL Scientists
3:00-3:15pm Break
3:15-4:15pm Case Studies from NCL Characterization - NCL Scientists
4:15-4:45pm Panel Discussion - NCL Scientists
4:45-5:00pm Meeting Wrap Up and Concluding Remarks - Scott McNeil

General Information

For conference related questions please contact the NCL at 301.846.6939 or ncl@mail.nih.gov

Location


Fishers Lane
Conference Center
5635 Fishers Lane
Rockville, MD 20852

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