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AIDS and Cancer Virus Program
The AIDS and Cancer Virus Program is a multidisciplinary group within NCI at Frederick that researches retroviruses and cancer-inducing viruses and their effects on the host.
Within the Program, the Retroviral Assembly Section studies cellular and viral aspects of HIV-1 assembly and applies the unique properties of retroviruses to the study of biological questions . One of our approaches is to study the host proteins incorporated inside and on the surface of HIV-1.
We want this database of cellular proteins in HIV-1 to be useful to the scientific community. Please share comments, questions, corrections or additions with us (ottde@mail.nih.gov)). Also, please share your newly published protein discoveries and procedures using the links on the left of this page.
This database is exportable by clicking the "export database" button on the "Host proteins in HIV-1" page.
Why study cellular proteins in HIV-1?
HIV-1 incorporates many cellular proteins during assembly and budding. These proteins can be incorporated:
- As bystanders who happen to be present at the site of HIV-1 budding
- As partners who assist assembly and are taken up by HIV-1 as it buds from the cell
- As proteins that are hijacked by HIV-1 to perform post assembly functions for the virus
The presence of these proteins provides potential clues to the localization of the assembling virus in the cell, proteins and the pathways that HIV-1 uses for assembly and release, and the ways in which HIV-1 virions infect new cells and interact with its host.
Additional information is available in our recent review
Due to multiple proteins names in current use, we strongly advise that searches be made with Uniprot accession numbers
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