LASP logo   NCI-Frederick
  
spacer
  clear pixel clear pixel

Speed Congenics

Recipient genome content in a conventional backcross

Figure 1: Recipient genome content in a conventional backcross

Traditionally, congenic mice are generated by random sequential backcrossing into the target (recipient) strain. With each generation the amount of donor strain DNA decreases on average by 50%. It may take up to 2.5 years to produce a congenic strain (backcross generation N10) containing 99.9% of the recipient genome.

(Return to LASP Speed Congenics Services)

  National Cancer Institute (NCI)      National Institutes of Health (NIH)      Department of Health and Human Services (HHS)      FirstGov.gov