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Phenotyping of Genetically Engineered Mice (GEM)/ Mouse Modeling

Trans NIH mouse initiative

Manuscripts:

    Kim, B.G., Li, C., Qiao, W., Mamura, M., Kasprzak, B., Anver, M., Wolfraim, L., Hong, S., Mushinski, E., Potter, M., Kim, S.J., Fu, X.Y., Deng, C., Letterio, J.J. Smad4 Signalling in T Cells is required for suppression of gastrointestinal cancer. Nature, Jun 22; 441 (7096): 1015-9, 2006

    Nunez, N.P., Oh, W.J., Rozenberg, J., Perella, C., Anver, M.R., Barrett, J.C., Perkins, S.N., Berrigan, D., Moitra, J., Varticovski, L., Hursting, S.D., Vinson, C. Accelerated Tumor Formation in a Fatless Mouse with Type 2 Diabetes and Inflammation. Cancer Research 2006; 66:5469-5476, 2006

    Birger, Y., Catez, F., Furusawa, T., Lim, J.H.., Prymakowska-Bosak, M., West, K.L., Postnikov, Y.V., Haines, D.C., Bustin, M. Increased tumorigenicity and sensitivity to ionizing radiation upon loss of chromosomal protein HMGN1. Cancer Research 65: (15), 2005

    Carlson, B.A., Novoselov, S.V., Kumaraswamy, E., Lee, B.J., Anver, M.R., Gladyshev, V.N., Hatfield, D.L. Specific excision of the selenocysteine tRNA [Ser]Sec ( Trsp ) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. Journal of Biological Chemistry 2004; 279(9): 8011-8017.

    Hussain, S.P., Trivers, G.E., Hofseth, L.J., He, P., Shaikh, I. , Mechanic, L., Doja, S., Jiang, W., Subleski, J., Shorts, L., Haines, D., Laubach, V.E., Wiltrout, R.H., Djurickovic, D., Harris, C.C. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. (2004) Cancer Research 64: 6849-6853.

    Wakefield , L.M., Thordarson, G., Nieto, A.I., Shyamala, G., Galvez, J.J., Anver, M.R. , Cardiff , R.D. Spontaneous pituitary abnormalities and mammary hyperplasias in FVB/NCr mice: implications for mouse modeling. Comparative Medicine 2003; 53(4): 424-432

    Wolff, L., Koller, R., Hu, X., Anver, M.R. A moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms. Journal of Virology 2003; 77(8): 4965-4971

    Tang, B., Vu, M. Booker, T., Santner, S.J., Miller, F.R., Anver, M.R. , Wakefield , L.M. TGF- switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J. Clin. Invest. 2003; 112(7): 1116-1124.

    Yang, Y., Dukhanina, O., Tang, B., Mamura, M., Letterio, J., MacGregor, J., Patel, S., Khozin, S., Green, J., Anver, M. , Merlino, G., Wakefield , L. Lifetime exposure to a soluble TGF-B antagonist protects mice against metastasis without adverse side-effects. J Clin Invest 2002; 109: 1607-1615

    Naramura, M., Jang, I.K., Kole, H., Huang, F., Haines, D., Gu, H. c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down -modulation. (2002) Nat Immunol 3(12): 1192-9.

    Berrigan, D., Perkins, S.N., Haines, D.C., Hursting , S.D. Adult -onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice. (2002) Carcinogenesis 23(5): 817-822.

    Sharp, R., Recio, J.A., Jhappan, C., Otsuka, T., Liu, S., Yu, Y., Liu, W., Anver, M.R. , Navid, F., Helman, L.J., DePinho, R.A., Merlino, G. Synergistic between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis. Nature Medicine 2002; 8(11): 1276-1280.

    Recio, J.A., Noonan, F.P., Takayama, H., Anver, M.R. , Duray, P., Rush, W.L., Lindner, G., DeFabo, E.C., DePinho, R.A., Merlino, G. Ink4a/Arf deficiency promotes ultraviolet radiation-induced melanomagenesis. Cancer Research 2002; 62: 6724-6730.

    Hollander, M.C., Kovalsky, O., Salvador , J.M., Kim, K.E., Patterson, A.D., Haines, D.C. , Fornace, A.J., Jr. DMBA carcinogenesis in Gadd45a -null mice is associated with decreased DNA repair and increased mutation frequency (2001) Cancer Research 61 (6):2487-91

    Welniak, L.A, Khaled, A.R., Anver, M.R. , Komschlies, K.L., Wiltrout, R.H.,Durum,., Ruscetti, F.R, Blazar, B.R., Murphy, W.J. Gastrointestinal cells of IL-7 receptor null mice exhibit increased sensitivity to irradiation. The Journal of Immunology 166:2923-2928, 2001

    Noonan, F.P., Reci, J.A., Takayama, H., Duray, P., Anver, M.R. , Rush, W.L., De Fabo, E. C., Merlino, G. Neonatal sunburn and melanoma in mice. Nature 413:271-272, 2001.

    Haines, D.C., Chattopadhyay, S., Ward, J.M. The Pathology of Aging B6;129 Mice (2001) Toxicol Pathol 29:653-661.

    Ward, J.M., Yoon, M., Anver, M.R., Haines, D.C . , Kudo, G., Gonzalez, F.J., Kimura, S. Hyalinosis and Ym1/Ym2 gene expression in the stomach and respiratory tract of 129S4/SvJae and wild-type and CYP1A2-null B6,129 mice (2001) American Journal of Pathology 158:323-332

    Green, J., Shibata, M-A., Yoshidome, k., Liu, M-L., Jorcyk, C., Anver, M., Wigginton, J., Wiltrout, R., Shibata, E., Kaczmarczyk, S., Wang, W., Liu, Z., Calvo, A., Couldrey, C. The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression of carcinoma. Oncogene 19:1020-1027, 2000.

    Maroulakou, I.G., Shibata, M., Anver, M. , Jorcyk, C.L., Liu, M., Roche, N., Roberts, A.B., Tsarfaty, I. , Reseau, J., Ward, J., and Green, J.E. Heterotopic endochondrial ossification with mixed tumor formation in C3(1)/Tag transgenic mice is associated with elevated TGF-beta1 and BMP-2 expression. Oncogene 18: 5435-5447, 1999

    Otsuka, T., Takayama, H., Sharp, R., Celli, G., LaRochelle, W., Bottaro, D., Ellmore, N., Vieira, W., Owens, J., Anver, M. , Merlino, G. c-Met Autocrine Activation Induces Development of Malignant Melanoma and Acquisition of the Metastatic Phenotype. Cancer Research 58: 5157-5167, 1998

    Tang, B., Bottinger, E., Jakowlew, S., Bagnall, K., Mariano, J., Anver, M. , Letterio J., Wakefield , L. Transforming Growth Factor-1 is a New Form of Tumor Suppressor with True Haploid Insufficiency. Nature Medicine Vol. 4, No. 7: 802-807, 1998

    Perkins, S., Hursting, S., Phang, J., Haines, D. Calorie Restriction Reduces Ulcerative Dermatitis and Infection-related Mortality in p53-deficient and Wild-type Mice (1998) The Journal of Investigative Dermatology, Vol. 111, No. 2:292-296

    Bottinger, E., Jakubczak, J., Haines, D., Bagnall, K., Wakefield , L. Transgenic Mice Overexpressing a Dominant Negative Mutant Type II TGF- Receptor Show Enhanced Tumorigenesis in the Mammary Gland and Lung in Response to the Carcinogen 7,12-dimethylbenz-[a]-anthracene Cancer Research, 57:5564-5570 (1997)

    Hursting, S., Perkins, S., Brown, C., Haines, D., Phang, J. Calorie Restriction Induces a p53-Independent Delay of Spontaneous Carcinogenesis in p53-Deficient and Wild Type Mice. Cancer Research 57:2843-2846 (1997)

    Perkins, S., Hursting, S, Haines, D., Jill, J., Barbara, M., Phang, J. Chemoprevention of Spontaneous Tumorigenesis in Nullizygous p53-deficient mice by Dehydroepiandrosterone and Its Analog, 16a-fluoro-5-androsten-17-one. Carcinogenesis Vol.18, No.5:pp989-994 (1997)

    ursting , S.D. , Perkins, S.N., Haines, D.C., Ward, J.M., Phang, J.M.) Chemoprevention of Spontaneous Tumorigenesis in p53-Knockout Mice. Cancer Research. 55:pp3949-3953 (1995)

Powerpoint presentation:
Pathology and Histology in Phenotyping a Mouse Model
Miriam R. Anver, DVM, PhD, Diplomate, ACVP,
Sr. Staff Pathologist, PHL

Rat

Book chapter:

    Copeland [Haines], D., Eustis, S. Specialized Modified Sebaceous Glands (Zymbal, Preputial, Anal, Clitoral) in Pathology of the F344 Rat. Boorman, G. ed. Academic Press, Inc., 279-293 (1990)

    Anver, M.R. In Jones, T.C., et al. eds. Lipoma, Subcutis, Rat; Liposarcoma, Subcutis, Rat. Monographs on Pathology of Laboratory Animals. Integument and Mammary Glands. Springer-Verlag , Berlin , 1989.

Manuscript:

    Waalkes, M., Anver, M., Diwan, B. Chronic Toxic and Carcinogenic Effects of Oral Cadmium in the Noble (NBL/Cr) Rat: Induction of Neoplastic and Proliferative Lesions of the Adrenal, Kidney, Prostate, and Testes. Journal of Toxicology and Environmental Health, Part A, 58:199-214, 1999.

    McKenna, I. , Melo, Gordon, T., Chen, L., Anver, M., Waalkes, M. Expression of Metallothionein Protein in the Lungs of Wistar Rats and C57 and DBA Mice Exposed to Cadmium Oxide Fumes. Toxicol. Appl. Pharmacol. 153:169-178, 1998.

    Lucia, S.M., Anzano, M., Slayter, M., Anver, M., Green, D., Shrader, M., Logsdon, D., Driver, C., Brown, C., Peer, C., Roberts, A., Sporn, M. The Chemopreventive Activity of Tamoxifen, N-(4-hydroxyphenyl) Rentiamide, and the Vitamin D Analogue Ro24-5531 for Androgen-promoted Carcinomas of the Rat Accessory Sex Gland. Cancer Research Vol. 55: 5621-5627, 1995.

    Lijinsky, W., Pegg, A.E., Anver, M.R. and Moschel, R.C. The effects of inhibition of O 6 alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea. Jap. Journal Cancer Res. 85: 226-230, 1994.

    Anver, M.R. , Cohen, B.J., Lattuada, C.P. and Foster, S.J. Age-associated lesions in barrier=reared male Sprague-Dawley rats: A comparison between Hap:(SD) and Crl:CD BS(R)(SD) stocks. Exp. Aging Res. 8: 1-24, 1982.

     

Fish

The Zebrafish Information Network
The Zebrafish book
Trout histology

    Brenniman, G.R., Anver, M.R. , Hartung, R. and Rosenberg , S.H. Effects of outboard motor exhaust emissions on goldfish (Carassius auratus). J. Environ. Pathol. Toxicol. 2: 791-796, 1979.

    Volker, F.A., Anver, M.R. , McKee, A.E., Casey, H.W. and Brenniman, G.R. Amebiasis in goldfish. Vet Pathol. 14: 247-255, 1977.

Frog

Xenbase: a Xenopus web resource
Xenopus links

Book chapter:

    Anver, M.R. , and Pond, C.L. Diseases and biology of amphibians. Fox, J.G., Cohen, B.J. and Loew, F.W., eds. In: Laboratory Animal Medicine. Academic Press, New York , 1984.

    Anver, M.R. In Kaiser, H.E., ed. Metastases in amphibians. Cancer Growth and Progression. Comparative Aspects of Tumor Development. Kluver Academic Publishers, Dordrecht , 1989.

    Wilcke, B.W., Newcomer, C.E., Anver, M.R., Simmons, J.L. and Nace, G.W. Isolation of Chlamydia psittaci from African clawed frogs (Xenopus laevis). Infect. Immun. 41: 789-794, 1983.

Manuscript:

    Anver, M.R. Amphibian Tumors: A Comparison of Anurans and Urodeles. In Vivo. 6:435-437,1992.

Comparative Pathology

Manuscripts:

    Mbulaiteye SM, Sternberg LR , Nsubuga MM, Anver MR, Mehta M, Biryahwaho B, Kambugu F, Rabkin CS, Robert J: Absence of Y-chromosome sequences in tumors from African women with AIDS-related Kaposi sarcoma. Cancer Letters, August 23, 2006 (PMID: #16934394)

    Kovacs, J.A., Lempicki, R.A., Sidorov, I., Adelsberger, J.W., Herpin, B., Metcalf, J.A., Sereti, I., Polis, M.A., Davey, R.T., Tavel, J., Falloon, J., Stevens, R., Lambert, L., Dewar, R., Schwartzentruber, D.J., Anver, M.R. , Baseler, M.W., Masur, H., Dimitrov, D.S., Lane, H.C. Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. Journal of Experimental Medicine 194(12):1731-1741, 2001.

    Ratnasinghe, D., Tangrea, J., Roth, MJ., Dawsey, SM., Anver, MR. , Kasprzak, BA., Hu, N., Wang, QH., Taylor , PR. Expression of Cyclooxygenase-2 in Human Adenocarcinomas of the Gastric Cardia and Corpus. Oncology Reports 6:965-968, 1999.

    Ratnasinghe, D., Tangrea, J., Roth, M.J., Dawsey, S., Hu, N., Anver, M. , Taylor, P.R. Expression of cyclooxygenase-2 in Human Squamous Cell Carcinoma of the Esophagus; an immunohistochemical Survey. Anti-Cancer Research 19(1A):171-174, 1999.

Embryo

An Atlas of Xenopus Embryogenesis
Axeldb database

Manuscripts:

    Durkin , M.E. , Anver, M.R. , Huh, C.G., Yuan, B.Z., Thorgeirsson, S.S., Popescu , N.C. DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Letters 2005, 579: 1191-1196.

    Geiman, T.M, Tessarollo, L., Anver, M.R. , Kopp, J.B, Ward, J.M., Muegge, K. Lsh, a SNF2 family member, is required for normal murine development and kidney function. Biochimica Biophysica Acta 1526(2):211-220, 2001

Aberrant crypt foci

Manuscripts:

    Colbert LH, Mai V, Perkins SN, Berrigan D, Lavigne JA, Wimbrow HH, Alvord WG, Haines D.C. , Srinivas P, Hursting SD. Exercise and intestinal polyp development in APCMin mice. Med Sci Sports Exerc. 2003 Oct;35(10):1662-9.
    PMID: 14523302 [PubMed - indexed for MEDLINE]

    Mai, V., Colbert, L.H., Berrigan, D., Perkins, S.N., Pfeiffer, R., Lavigne, JA, Lanza, E., Haines, D.C ., Schatzkin, A., Hursting, S.D. Calorie restriction and diet composition modulate spontaneous intestinal tumorigenesis in Apc Min mice through different mechanisms. (2003) Cancer Research 63(8): 1752-1755.

    Greiner, J.W., Zeytin, H., Anver, M.R. , Schlom, J. Vaccine-Based Therapy Directed Against Carcinoembryonic Antigen Demonstrates Antitumor Activity on Spontaneous Intestinal Tumors in the Absence of Autoimmunity. Cancer Research 2002; 62: 6944-6951

Immuno Histopathology

Immunology Antibody Database

Manuscript:

    Jhappan, C., Yusufazai, T., Anderson , S., Anver, M. , Merlino, G. The p53 Response to DNA Damage in vivo is DNA-PK Independent. Molecular and Cellular Biology 20:4075-4083, 2000.

Photomicrograph

(link to thumbnail photos including Cancer Research front cover)

Manuscript:

    Hildesheim , J., Bulavin, D.V., Anver, M.R. , Alvord, W.G., Fornace Jr., A.J. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via stress MAPK kinases and p53. Cancer Research 2002; 62: 7305-7315

American College of Veterinary Pathology

Support other NIH institutions

Manuscript:

    Murray, G, Anver, MR, Kennedy, MA, Quirk, JM, Schiffmann, R. Cellular and tissue Distribution of Intravenously Administered Agalsidase Alfa. Molecular Genetics and Metabolsim Mol Genet Metab 90(3): 307-12, 2007 (PMID: #17188539) [NINDS]

    Moayeri M, Haines D , Young HA, Leppla SH. toxicity in mice. Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated J Clin Invest. 2003 Sep;112(5):670-82. PMID: 12952916 [PubMed - indexed for MEDLINE]

    Franzoso, G., Carlson, L., Poljak, L., Shores, E., Epstein, S., Leonardi, A., Grinberg, A., Tran, T., Scharton-Kersten, T., Sher, A., Anver, M., Lover, P., Brown, K., Siebenlist, U. Mice Deficient in Nuclear Factor (NF)-?B/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture. Journal of Experimental Medicine Vol. 187, No. 2: 147-159, 1998 [NIAID]

    Franzoso, G., Carlson, L., Scharton-Kersten, T., Shores, E., Epstein, S., Grinberg, A., Tran, T., Shacter, E., Leonardi, A., Anver, M., Love, P., Sher, A., Siebenlist, U. A Critical Role for the Bcl-3Oncoprotein in Development of Germinal Centers and Adaptive Immunity. Immunity Vo. 6, 479-490, 1997 [NIAID]

MMHCC nomenclature workshops

MMHCC:  http://emice.nci.nih.gov/

Manuscripts:

    Hruban, R.H., Adsay, N.V., Albores-Saavedra, J., Anver, M.R ., Biankin, A.V., Boivin, G.P., Furth, E.E., Furukawa, T., Klein, A., Klimstra, D.S., Kloppel, G., Lauwers, G.Y., Longnecker, D.S., Luttges, J., Maitra, A., Offerhaus, G.J.A., Perez-Gallego, L., Redston, M., Tuveson, D.A. Pathology of Genetically Engineered Mouse Models of Pancreatic Exocrine Cancer: Consensus Report and Recommendations. Cancer Research 2006; 66:95-106, 2006

    Nikitin, A.Y., Alcaraz, A., Anver, M.R., Bronson, R.T., Cardiff, R.D., Dixon, D., Fraire, A.E., Gabrielson, E.W., Gunning, W.T., Haines, D.C., Kaufman, M.H., Linnoila, R.I., Maronpot, R.R., Rabson, A.S., Reddick, R.L., Rehm, S., Rozengurt, N., Schuller, H.M., Shmidt, E.N., Travis, W.D., Ward, J.M., Jacks, T.  Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancer Consortium. (2004) Cancer Research 64: 2307-2316.

    Morse III, H.C., Anver, M.R. , Fredrickson, T.N., Haines, D.C ., Harris, A.W., Harris, N.L., Jaffe, E.S., Kogan, S.C., Maclennan, I.C.M., Ward, J.M. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood 2002; 100(1): 246-258.

    Kogan, S.C., Ward, J.M., Anver, M.R. , Berman, J.J., Brayton, C., Cardiff, R.D., Carter, J.S., de Coronado, S., Downing, J.R., Fredrickson, T.N., Haines, D.C ., Harris, A.W., Harris, N.L., Hiai, H., Jaffe, E.S., MacLennan, I.C.M., Pandolfi, P.P., Pattengale, P.K., Perkins, A.S., Simpson, R.M., Tuttle, M.S., Wong, J.F., Morse, H.C. III Bethesda Proposals for Classification of Non-Lymphoid Hematopoietic Neoplasms in Mice. Blood 2002; 100(1): 238-245.

    Cardiff , R.D., Anver, M.R. , Gusterson, B.A., Heninghausen, L., Jensen, R.A., Merino, M.J., Rehm, S., Russo, J., Tavassoli, F.A., Ward, J.M., Wakefield , L.M., and Green, J.E. The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene 19:968-988, 2000.

National

Presentations:

    Anver, MR , Ward, JM, Carlson, BA, Perella, C, Rogers , K , Gladyshev, VN, Hatfield, DL. Pyogranulomatosis in Selenium-Deficient Transgenic Mice. STP Annual Meeting, June 19-23, 2005, Washington , DC

    Anver, MR , Carlson, BA, Novoselov, SV, Kumaraswamy, E, Lee, BJ, Gladyshev, VN, Hatfield, DL. Specific Excision of the Selenocysteine tRNA {Ser} Sec (Trsp) Gene in Mouse Liver Induces Lethal Hepatocellular Apoptosis. STP Annual Meeting, June 13-17, 2004, Salt Lake City , UT

    Smith, C.D., Anver, M.R., Haines, D.C., Herring, J.M., Hollingshead, M.G., Gorelick, P.L., Ward, J.M. Fatty liver in mouse hepatitis virus (MHV) infection in SCID/NCr mice. 2003 Conference Proceedings Annual ACVP Mtg., November 15-19, 2003.

    Ward, J.M., Anver, M.R., Haines, D.C.Pathology of mouse models of human cancer. ACVP Annual Meeting, New Orleans , December 2002.

    Haines, D., Ward, J. Otitis media in aging B6,129 mice. Pathology of Mutant Animal Models 2002, Houston , TX , February 12-16, 2002.

NIH Mouse 101

Powerpoint presentation:

    MOUSE 101 Histopathology (2005)
    Diana C. Haines, DVM, Diplomate, ACVP

    (link title, MOUSE 101 Histopathology (2005), to File: HistoPath MOUSE 101 (on NIH Mouse 101 Course Presentations disk))

Web cast (NIH only):

    Imaging Mice, Imaging Tumors, Murine Histology and Murine Pathology (NIH Only)
    Monday, May 23, 2005
    M. Simpson, S. Libutti , M. Anver and D. Haines
    Total Running Time: 02:00:13

http://videocast.nih.gov/PastEvents.asp?c=18&s=21

http://videocast.nih.gov/ram/mouse052305.ram

Book Chapters

Anver, M.R., Haines, D.C .   Gerontology.  In: The Laboratory Mouse Handbook.  (2004)   Academic Press, Chapter 21: 327-343.

Betton, G.R., Whiteley, L.O., Anver, M.R. , Brown, R., Deschl, U., Elwell, M., Germann, P.-G., Hartig, F., Kuttler, K., Mori, H., Nolte, T., Puschner, H., Tuch, K. Gastrointestinal Tract. In: International Classification of Rodent Tumors - The Mouse. Editor Ulrich Mohr, Springer, Berlin , pp. 23-58, 2001

Ward, J.M., Anver, M.R. , Mahler, J.F., Devor-Henneman, D.E. Pathology of Mice Commonly Used in Genetic Engineering (C57BL/6,129, B6,129 and FVB/N). In: Pathology of Genetically Engineered Mice. eds. Ward, J.M., Mahler, J.F., Maronpot, R.R., Sundberg, J.P. Chapter 13, pp. 161-179, 2000.

Chalifoux, L.V. and Anver, M.R. Cholesterol gallstones in owl monkeys. In: Nonhuman Primates II. eds Jones, T.C. et al Springer-Verlag Berlin , pp 63-64, 1993.

Copeland [Haines], D ., Eustis, S. Specialized Modified Sebaceous Glands (Zymbal, Preputial, Anal, Clitoral) in Pathology of the F344 Rat. Boorman, G. ed. Academic Press, Inc., 279-293 (1990)

Animal Health Surveillance

Manuscript:

    Haines, D.C ., Gorelick, P.L., Battles, J.K., Pike, K.M., Anderson, R.J., Fox, J.G., Taylor, N.S., Shen, Z., Dewhirst, F.E., Anver, M.R., Ward, J.M. Inflammatory large bowel disease in immunodeficient rats naturally and experimentally infected with Helicobacter bilis (1998) Vet. Pathol., Vol. 35, No. 3:202-208

    Sipowicz, M., Chomerat, P., Diwan, B., Anver, M., Awasthi, Y., Ward, J., Rice, J., Kasprzak, K., Wild, C., Anderson , L. Increased Oxidative DNA Damage and Hepatocyte Overexpression of Specific Cytochrome P450 Isoforms in Livers of Mice Infected with Helicobacter hepaticus. Am. Journal Pathol., Vol. 151, No. 4: 933-941, 1997

    Sipowicz, M., Chomerat, P., Diwan, B., Anver, M., Awasthi, Y., Ward, J., Rice, J., Kasprzak, K., Wild, C., Anderson , L. Increased Oxidative DNA Damage and Hepatocyte Overexpression of Specific Cytochrome P450 Isoforms in Livers of Mice Infected with Helicobacter hepaticus. Am. Journal Pathol., Vol. 151, No. 4: 933-941, 1997

    Ward, J.M., Anver, M.R., Haines, D.C. , Melhorn, J.M., Gorelick, P., Yan, L., Fox, J.G. Inflammatory Large Bowel Disease in Immunodeficient Mice Naturally Infected with Helicobacter hepaticus . Lab. Animal Sci. Vol.55, No.1, (1996)

    Russell, R., Haines, D ., Gorelick, P., Gonda, M, Ward, J., Blumenauer, L., Anver, M ., Battles, J. Use of Antibiotics to Prevent Hepatitis and Typhilitis in Male SCID Mice Spontaneously Infected with Helicobacter hepaticus . Lab. An. Sci. 45:4,373-378 (1995)

    Ward, J.M., Fox, J.G., Anver, M.R., Haines, D.C. , et al. Chronic Active Hepatitis and Associated Liver Tumors in Mice Caused by a Persistent Bacterial Infection with a Novel Helicobacter Species. J. Nat. Cancer Inst. 86:1222-1227 (1994)

    Ward, J.M., Anver, M.R., Haines, D.C., and Benveniste, R.E. Chronic Active Hepatitis in Mice Caused by Helicobacter hepaticus . Am. J. Path. 145:959-968 (1994)

Other Links

Antibody Resource page

Mouse genome informatics (jax lab)

Histology Atlas of the Mouse Mammary gland

Mouse tumor biology database (Jax lab)  

Comparative Medicine Branch, NIAID

Related Links

 

 

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