Laboratory Animal Sciences Program
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Pathology

PHL pathologists function as scientific collaborators assisting in animal study design, species selection, histopathology and immunohistopathology evaluation, photomicrography, report and manuscript preparation. This is in keeping with NCI-Frederick's research mission.

ANIMAL STUDY DESIGN:

  • Review pertinent literature including interpretation of previous pathology data. Advise on mouse modeling/phenotyping, and appropriate controls.

  • Recommendations for hematology, blood chemistry , special stains or immunohistochemistry.
  • Development of specialized necropsy protocols including choice of fixative(s). Individualized trimming procedures including cost effective selection of target organs.

SPECIES:

HISTOPATHOLOGICAL EVALUATION:


Article in Cancer Research:
Hildesheim, J., Bulavin, D.V., Anver, M.R., Alvord, W.G., Fornace Jr., A.J. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via stress MAPK kinases and p53. Cancer Research 2002; 62: 7305-7315

IMMUNO HISTOPATHOLOGY:

  • Optimization of antibodies
  • Apoptosis
  • Cell proliferation
  • Angiogenesis
  • Hematopoietic neoplasm subclassification

PHOTOMICROGRAPH AND IMAGE ANALYSIS:

  • For presentations or manuscripts. Olympus® Vanox microscope equipped with digital and 35 mm film cameras.
  • Currently developing investigator-friendly link through the internet.

REPORTS:

  • Computerized necropsy/pathology data system with capacity to generate summary incidence reports.
  • Email reports directly to investigators.
  • Generation of Methods, Pathology tables, Pathology sections for manuscripts.

EXPERTISE:

INTERACTION:
Interaction is facilitated by our on-site location for NCI-Frederick investigators and the shuttle service between NIH, Bethesda, and Frederick, as well as phone, fax, and electronic mail. PHL’s staff is proactive in developing new techniques, including molecular pathology techniques to support research projects. Our contributions to various research projects are reflected by inclusion as co-authors on numerous scientific manuscripts.

OTHER LINKS

  National Cancer Institute (NCI)      National Institutes of Health (NIH)      Department of Health and Human Services (HHS)      FirstGov.gov  
 
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