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MDSS Seminar Speaker - Dr. Michelle Arkin - March 1, 2018 “Tackling Challenging Drug Targets, a Biophysical Perspective”

When

Thursday, March 1, 2018

10:00 AM - 11:00 AM

Where

NCI at Frederick, 376 Conference Room 121

Questions?

Dina Sigano 301-846-5995

Event Type

Seminar

Event Description

Protein-protein networks are critical regulators of health and disease, yet are widely considered “undruggable” or, at best, “challenging.” Our long-term goal is to understand the features that lead to drug-like binding to protein interfaces and to develop small-molecule modulators of protein interaction networks. For example, the AAA ATPase p97/VCP is hypothesized to couple with more than two dozen ‘adaptor’ proteins to support protein degradation and trafficking in multiple organelles. We are developing tool compounds that modulate p97 activity through multiple mechanisms of action. We are also utilizing the disulfide-trapping technique to discover novel inhibitors and stabilizers of protein-protein interactions.

Featured Speaker(s)

Dr. Michelle Arkin University of California, San Francisco
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