When
April 26 - 27 2018
09:00 AM - 01:00 PM
Where
NCI at Frederick, 549 Conference Center
Event Type
Conference
Event Description
The HIV-1 envelope (Env) glycoprotein complex is a heterotrimer comprising 3 molecules each of the surface glycoprotein gp120 and the transmembrane glycoprotein gp41. The Env complex is essential for virus entry into the target cell, as it binds receptor and coreceptor and mediates the fusion between viral and cellular membranes. Lentiviruses are unique among retroviruses in having transmembrane glycoproteins with very long cytoplasmic tails (approximately 150 amino acids in the case of HIV-1).
The structure and function of gp120 and the ectodomain of gp41 are relatively well understood. In contrast, although it is well established that the long gp41 plays crucial roles in Env trafficking, internalization, incorporation into virions, and ectodomain conformation, the structure and function of the cytoplasmic tail has remained enigmatic. This workshop brings together a majority of groups working on this important biological problem for informal short talks and discussion.
Hosted By
CCR - Dr. Freed