NCI Mouse Repository

The NCI Mouse Repository is an NCI-funded resource for mouse cancer models and associated strains. The repository makes strains available to all members of the scientific community (academic, non-profit, and commercial). NCI Mouse Repository strains are cryoarchived and distributed as frozen embryos.

MicroRNAs (miRNAs) are small non-coding RNA molecules known to play an important role in fundamental cellular processes through negative post-transcriptional regulation of gene expression. In an effort to address the role that microRNAs play in human cancer, their use as diagnostic tools, and their potential function as new targets for therapeutic intervention in the treatment of cancer, the Division of Cancer Biology (DCB) of the National Cancer Institute (NCI) has supported the generation of mouse embryonic stem cells (mESCs) harboring most known mouse miRNAs. In order to enhance novel information obtained on their role in cancer, 1501 genetically engineered mESC lines were produced, harboring conditional microRNA transgenes.