Available Strain Details

Strain Information
Common Strain Name: ROSA26-pCAGGs-LSL-Luciferase Pricing and Ordering Information
Strain Nomenclature: B6.129-Gt(ROSA)26Sortm2(ACTB-Luc)Tyj/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B3,D


Strain Description: A Cre-inducible luciferase transgene was targeted into the Rosa26 locus and is driven by a CMV-based promoter. This allele when used in combination with Cre-regulated oncogenes or tumor suppressors can allow for noninvasive detection of tumors in mice. This allele permits serial imaging of mice, thus increasing the utility of mouse tumor models as a system to test therapeutics.
Mutation Information
Mutation Type: Targeted
Gene Name: gene trap ROSA 26, Philippe Soriano
Gene Symbol: Gt(ROSA)26Sor
Transgene Name:
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Current Genetic Background: B6.129
Approx. Generation: 21
Organ Site: Various
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype C57BL/6 (male or female). Average litter size is 8. Homozygotes are viable but breed as heterozygotes for increased fertility.
Genotyping Information: Protocol 1: Allele: Gt(ROSA)26<tm2(ACTB-Luc)Tjy
Donating Investigator: Dr. Tyler Jacks

Key Reference:

Sponsor: Howard Hughes Medical Insititute, 5-U54-CA112967-03