Available Strain Details

Strain Information
Common Strain Name: Pax3:Fkhr conditional knock-in Pricing and Ordering Information
Strain Nomenclature: B6;129-Pax3tm1Mrc/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): C1,D


Strain Description: Germline activation leads to exencephaly; Cre activation in muscle lineages leads to alveolar rhabdomyosarcoma tumors.
Mutation Information
Mutation Type: Targeted
Gene Name: Paired-box 3
Gene Symbol: Pax3
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129
Approx. Generation: homo
Organ Site: Any tissue
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is homozygous x homozygous. When maintained as a live colony, breeder pairs were distributed as homozygotes. Average litter size is 6-8. Donating investigator recommends maintaining stock breeders as homozygous without Cre.
Genotyping Information: Protocol 1: Allele: Pax3<tm1Mrc>
Donating Investigator: Dr. Charles Keller

Key Reference: Keller C, Hansen MS, Coffin CM, Capecchi MR. Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA. Pubmed ID 15520281 [Pubmed Abstract]

Related Reference: Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR. Division of Pediatric Hematology-Oncology and Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA. Pubmed ID 15489287 [Pubmed Abstract]