Available Strain Details

Strain Information
Common Strain Name: p53 floxed Pricing and Ordering Information
Strain Nomenclature: FVB.129P2-Trp53tm1Brn/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): C2,D


Strain Description: This strain carries a conditional mutation in the endogenous p53 gene (Trp53). LoxP sites were inserted into intron 1 and intron 10 of the p53 locus. Homozygous mice were monitored for one year with no increased tumor incidence over wild type controls. Crosses to mice expressing Cre in the germline show the same tumor spectrum as do conventional p53-null mice.
Mutation Information
Mutation Type: Targeted
Gene Name: Transformation related protein 53
Gene Symbol: Trp53
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: FVB.129
Approx. Generation: 29
Organ Site: various
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB Females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as heterozygotes.
Genotyping Information: Protocol 1: Allele: Trp53<tm1Brn>
Donating Investigator: Dr. Anton Berns

Key Reference: Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 29(4):418-25. PMID: 11694875 [Pubmed Abstract]

Related Reference: Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. 2000. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev. 14:994-1004. PMID: 10783170 [Pubmed Abstract]