Available Strain Details

Strain Information
Common Strain Name: Brca1 null, Brca1 KO Pricing and Ordering Information
Strain Nomenclature: STOCK Brca1tm1Cxd/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): C1


Strain Description: This strain carries a null mutation of Brca1. Homozygotes die at E7-8.
Mutation Information
Mutation Type: Targeted
Gene Name: Breast cancer 1
Gene Symbol: Brca1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: STOCK
Approx. Generation: 17
Organ Site: Breast
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is wild-type non-sibling STOCK females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygous (male or female) x wildtype non-sib (male or female).
Genotyping Information: Protocol 1: Allele: Brca1<tm1Cxd>
Donating Investigator: Dr. CX Deng

Key Reference: Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX. 1998. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene 17:3115-24. [Pubmed Abstract]