Available Strain Details

Strain Information
Common Strain Name: K14 Cre Pricing and Ordering Information
Strain Nomenclature: FVB-Tg(KRT14-cre)8Brn/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): C2,D


Strain Description: This strain expresses Cre recombinase under the control of the human K14 promoter. Expression was found in the skin, salivary gland and mammary-gland epithelium. In mammary gland activity was found in 5-35% of both luminal epithelial and myoepithelial cells. In addition, expression was in epithelial cells of several additional tissues, including tongue, esophagus, fore-stomach and thymus. No activity was found in ovaries.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Cre recombinase
Transgene Symbol: Cre
Promotor Name: keratin 14
Promotor Symbol: hK14
Current Genetic Background: FVB
Approx. Generation: 14
Organ Site: Skin
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB females x hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype FVB (male or female).
Genotyping Information: Protocol 1: Allele: Tg(KRT14-Cre)8Brn
Donating Investigator: Dr. Anton Berns

Key Reference: Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. 2001 Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 29:418-25. PMID: 11694875 [Pubmed Abstract]