Available Strain Details

Strain Information
Common Strain Name: Tsc1 Pricing and Ordering Information
Strain Nomenclature: B6;129S4-Tsc1tm1.1Djk/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B1


Strain Description: Tsc1(-/+) heterozygotes develop kidney cystadenomas and liver hemangiomas. Tsc1 null mutants die at mid gestation.
Mutation Information
Mutation Type: Targeted
Gene Name: Tuberois sclerosis
Gene Symbol: Tsc1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129S4
Approx. Generation:
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype C57BL/6 Sib (male or female).
Genotyping Information: Protocol 1: Allele: Tsc1<tm1.1Djk>
Donating Investigator: Dr. David Kwiatkowski

Key Reference: Kwiatkowski, D.J., Zang, H., Bandura, JL, Heiberger, K.M, Glogauer, M., Hashemite, N., Onda, H. 2002 A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11:525-534 PMID: 11875047 [Pubmed Abstract]