Available Strain Details

Strain Information
Common Strain Name: Mdm-2rec Pricing and Ordering Information
Strain Nomenclature: B6.129S7(Cg)-Mdm2tm1.1Mep/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B1,D


Strain Description: Murine strain carrying one allele of mdm2 in which exons 7-9 have been deleted by Cre recombinaton. Homozygous mice are embryonic lethal. Can be used in conjunction with a conditional allele to study tissue specific effects of mdm2 deletion.
Mutation Information
Mutation Type: Targeted
Gene Name: Murine double minute 2
Gene Symbol: Mdm2
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.129S7(Cg)
Approx. Generation:
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype C57BL/6 (male or female). The strain is maintained heterozygously on a B6 background.
Genotyping Information: Protocol 1: Allele: Mdm2<tm2Mep>
Donating Investigator: Dr. Mary Ellen Perry

Key Reference: Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, and Perry ME. 2003 mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation. Molecular and Cellular Biology 23:462-472 PMID: 12509446 [Pubmed Abstract]