Available Strain Details

Strain Information
Common Strain Name: HPV16-E6 Pricing and Ordering Information
Strain Nomenclature: FVB-Tg(KRT14-HPV16E6)5737Plam/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B1,D


Strain Description: This strain carries 15 copies of the K14-HPV16 E6 transgene. Hemizygous animals develop epithelial hyperplasia (wrinkled skin visible at 12 days of age), skin tumors, and cervical tumors (when crossed to K14E7 mice treated with estrogen). Skin tumors arise late in 14% of the mice (at 15 months of age, first onset at 6 months). Lesions are malignant, grade I-III epidermoid carcinomas. Cataracts are also apparent by weaning.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: human papillomavirus type 16
Transgene Symbol: HPV16
Promotor Name: human keratin
Promotor Symbol: hK14
Current Genetic Background: FVB
Approx. Generation: 17
Organ Site: Skin
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB Females x homozygous males. When maintained as a live colony, breeder pairs were distributed as Homozygotes. Late onset skin tumors (14% at 15 months of age). Pups can be identified by wrinkled skin at day 12. Cataracts are also apparent by weaning.
Genotyping Information: Protocol 1: Allele: Tg(hK14-HPV16-E6)5737Plam
Donating Investigator: Dr. Paul Lambert

Key Reference: Shiyu S, Pitot HC, and Lambert PF. 1999. The Human Papillomavirus Type 16 E6 Gene Alone Is Sufficient To Induce Carcinomas in Transgenic Animals. J. Virol. 73:5887-5893 PMID: 10364340 [Pubmed Abstract]