Available Strain Details

Strain Information
Common Strain Name: GFAP-hCDK4 Pricing and Ordering Information
Strain Nomenclature: ICR-Tg(GFAP-CDK4)2Gtm/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B1


Strain Description: These mice do not develop brain tumors but exhibit a small increase in astrocyte number. This mouse is useful for mouse modeling of human brain tumors. The genetic background is outbred (ICR).
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Human Cyclin dependent kinase-4
Transgene Symbol: hCDK4
Promotor Name: Glial fibrillary acidic protein
Promotor Symbol: GFAP
Current Genetic Background: ICR
Approx. Generation:
Organ Site: Brain
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme wildtype littermates x hemizygote males. When maintained as a live colony, breeder pairs were distributed as Hemizygotes.
Genotyping Information: Protocol 1: Allele: Tg(GFAP-hCDK4)2Gtm
Donating Investigator: Dr. David H. Gutmann

Key Reference: Huang Z, Baldwin RL, Hedrick NM, and Gutmann DH. 2002 Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates wit p53 heterozygosity to provide a growth advantage for astrocytes in vivo. Oncogene 21:1325-1334 PMID: 11857076 [Pubmed Abstract]