Available Strain Details

Strain Information
Common Strain Name: PB-FGF8b-line 3 Pricing and Ordering Information
Strain Nomenclature: B6D2F2-Tg(AAR2/Pbsn-FGF8)3Prb/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B1,D


Strain Description: The mice spontaneously developed prostatic epithelial hyperplasia by 2-3 months of age. The disease progressed to low-grade PIN by 5-7 months, and high-grade PIN (15-17 months), in a markedly stochastic pattern reminiscent of the slow progression of prostatic disease in humans. Within the two-year observation period, stromal hypercellularity and chronic inflammation were observed but no invasive cancer was found. This mouse model indicates that overexpression of Fgf8b is sufficient to drive proliferation in the prostatic epithelium.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Fgf8b
Transgene Symbol: Fgf8b
Promotor Name: ARR2PB rat (composite)
Promotor Symbol: ARR2PB
Current Genetic Background: B6D2F2
Approx. Generation: 5
Organ Site: Prostate
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is B6D2F1/Cr females x Hemizygous males . When maintained as a live colony, breeder pairs were distributed as hemizygotes. Average litter size is 8-12.
Genotyping Information: Protocol 1: Allele: Tg(ARR2/Pbsn-FGF8)3Prb
Donating Investigator: Dr. Pradip Roy-Burman

Key Reference: Song Z, Wu X, Powell WC, Cardiff RD, Cohen MB, Tin RT, Matusik RJ, Miller GJ, Roy-Burman P. Fibroblast growth factor 8 isoform B overexpression in prostate epithelium: a new mouse model for prostatic intraepithelial neoplasia. Cancer Res. 2002 Sep 1;62(17):5096-105. PMID: 12208767 [Pubmed Abstract]