Available Strain Details

Strain Information
Common Strain Name: Lkb1 flox Pricing and Ordering Information
Strain Nomenclature: FVB;129S6-Stk11tm1Rdp/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): B1,D


Strain Description: These mice carry a functional, conditional allele of Lkb1 (official gene symbol: Stk11) with LoxP sites flanking exons 3 and 6 (Stk11). These animals are phenotypically normal in absence of Cre recombination. Cre-mediated deletion of exons 3-6 lead to embryonic lethality in the homozygous state, whereas heterozygous mice developed gastrointestinal polyps (mucosal hamartomas) with histological features similar to those seen in Peutz-Jeghers syndrome (PJS) patients.
Mutation Information
Mutation Type: Targeted
Gene Name: serine/threonine kinase 11
Gene Symbol: Stk11
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: FVB;129S6
Approx. Generation: 36
Organ Site: GI tract
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is homozygous x homozygous. When maintained as a live colony, breeder pairs were distributed as homozygotes. Average litter size is 9.
Genotyping Information: Protocol 1: Allele: Stk11<tm1Rdp>
Donating Investigator: Dr. Ron DePinho

Key Reference: Bardeesy N; Sinha M; Hezel AF; Signoretti S; Hathaway NA; Sharpless NE; Loda M; Carrasco DR; DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419, 162-167, 2002. PubMed ID: 12226664. [Pubmed Abstract]

Sponsor: NCI MMHCC U01 CA84313-06