Available Strain Details

Strain Information
Common Strain Name: XPV knockout Pricing and Ordering Information
Strain Nomenclature: B6;129-Polhtm1Rak/Nci
Animal State: Cryoarchived Strains
Release Category (Required for MTA form): C1,D


Strain Description: The DNA polymerase eta gene (Polh, XPV) was inactivated by Cre-loxP mediated germline deletion of exon 4. Homozygous mice are fertile. Skin tumors can be induced 2~3-month after exposure to ultraviolet (UV) light with 100% frequency. No abnormal B-cell physiology has been observed.
Mutation Information
Mutation Type: Targeted
Gene Name: polymerase (DNA directed), eta (RAD 30 related)
Gene Symbol: Polh
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129
Approx. Generation: homo
Organ Site: Skin
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x homozygous males. When maintained as a live colony, breeder pairs were distributed as homozygote siblings. Average litter size is 8.
Genotyping Information: Protocol 1: Allele: Polh<tm1.1Rak>
Donating Investigator: Dr. Raju Kucherlapati

Key Reference: Qingcong Lin, Alan B. Clark, Scott D. McCulloch, Tao Yuan, Roderick T. Bronson, Thomas A. Kunkel, and Raju Kucherlapati. Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase eta-deficient Mice. Cancer Res. 66, 87-94, 2006. PMID:16397220. [Pubmed Abstract]

Sponsor: CA 084301 (NCI), ES11040 (NIEHS)