Science

Novel Vaccine Approach Achieves “Functional Cure” of AIDS Virus in Monkeys

Jeff Lifson, Brandon Keele, Jacob Estes, and Michael Piatak

By Frank Blanchard, Staff Writer, and Jeff Lifson, Guest Writer

Scientists at the Oregon Health & Science University and the AIDS and Cancer Virus Program of the Frederick National Laboratory for Cancer Research have used a novel vaccine approach to achieve a “functional cure” and apparent eradication of infection with a monkey version of the AIDS virus.

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New Approach for Producing and Purifying IL-15 Heterodimers That Have Potent Immune Effect

Elena Chertova and Cristina Bergamaschi

Platinum Highlight IconBy Nancy Parrish, Staff Writer

Cytokines are proteins that play a crucial role in the human immune system by delivering messages that trigger the activation of immune cells to fight off attacks from viruses or other invaders.

Cristina Bergamaschi, Ph.D., NCI Center for Cancer Research, has been studying the mechanism of expression and function of a cytokine known as interleukin-15 (IL-15) for the last five years, in collaboration with Elena Chertova, Ph.D., and other researchers in the Retroviral Protein Chemistry Core (RPCC) of the AIDS and Cancer Virus Program (ACVP), Frederick National Laboratory for Cancer Research.

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