Science

Inside the Scientific Arsenal: A Nobel-Prize-Winning Method for 3D Modeling

Every Monday morning, Ulrich Baxa, Ph.D., and his colleagues enter their Gaithersburg, Md., laboratory and begin calibrating their Titan Krios, a massive, $7-million transmission electron microscope that can capture high-definition images at near-atomic magnification. They load several flash-frozen biological samples into the Krios and, by 5 p.m., program the instrument to collect data. As the team leaves for the evening, the Krios begins shooting beams of energy into the samples and taking photos.

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Inside the Scientific Arsenal: The Two-Armed Tool That’s Faster Than a Scientist

Sitting at a computer in an NCI at Frederick laboratory, Todd Hartley writes an automated method for an experiment. With a final swipe of the mouse, he clicks an on-screen button that says “Run.” The large device sitting to his left, a Biomek FXP Laboratory Automation Workstation, whirrs to life. A robotic arm hovers over a deck containing various microplates then lowers a group of pipette tips to draw liquid from a reservoir, raises and moves again, and deposits the fluid in a nearby microplate with superhuman accuracy.

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Researchers Identify Possible Reason for Loss of Brain Function in Patients with ALS

A team of scientists in NCI at Frederick’s Center for Cancer Research Mouse Cancer Genetics Program and their collaborators at the University of Florence have identified a link between the presence of a growth factor receptor and cognitive impairments in patients with amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease). 

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