Examination of Genome-Wide Somatic Mutations
Contact Information: Dr. Brian T. Luke (301)846-5553
Examining the somatic mutations in tumors yields information about the underlying mutation/repair mechanisms.
A: Lung cancer (NSC)
B: Lung cancer (SC)
C: Malignant Melanoma (GWS)
D: Melanoma (EWS)
F: 1000 Genomes
These landscapes demonstrate that the mutation/repair mechanism is very similar between tumors
from the same tissue or origin, and between genome-wide sequencing (GWS) and exone-wide sequencing (EWS).
This methodology has been recently used to identify an APOBEC3B mutation signature in breast cancer
[Burns et al. APOBEC3B is an enzymatic source of mutation in breast cancer. Nature 2013:494:366-370].