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Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4(+) T Cells

  1. Author:
    Anderson, J. A.
    Archin, N. M.
    Ince, W.
    Parker, D.
    Wiegand, A.
    Coffin, J. M.
    Kuruc, J.
    Eron, J.
    Swanstrom, R.
    Margolis, D. M.

  2. Author Address

    [Anderson, JA; Archin, NM; Ince, W; Parker, D; Kuruc, J; Eron, J; Swanstrom, R; Margolis, DM] Univ N Carolina, Chapel Hill, NC 27599 USA [Wiegand, A; Coffin, JM] NCI, HIV Drug Resistance Program, NIH, Frederick, MD 21701 USA;Margolis, DM (reprint author), Univ N Carolina, 2060 Genet Med Bldg,CB 7042, Chapel Hill, NC 27599 USA;dmargo@med.unc.edu
    1. Year: 2011
    2. Date: May
  2. Journal: Journal of Virology
    1. 85
    2. 10
    3. Pages: 5220-5223
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    Despite successful antiretroviral therapy (ART), low-level viremia (LLV) may be intermittently detected in most HIV-infected patients. Longitudinal blood plasma and resting CD4(+) T cells were obtained from two patients on suppressive ART to investigate the source of LLV. Single-genome sequencing of HIV-1 env from LLV plasma was performed, and the sequences were compared to sequences recovered from limiting-dilution outgrowth assays of resting CD4(+) T cells. The circulating LLV virus clone was identical to virus recovered from outgrowth assays from pools of millions of resting CD4(+) T cells. Understanding the sources of LLV requires evaluation of all possible reservoirs of persistent HIV infection.

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External Sources

  1. View Full Text
  2. DOI: 10.1128/jvi.00284-11
  3. View record in Web of Science®
  4. WOS: 000289787300057

Library Notes

  1. Fiscal Year: FY2010-2011
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