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New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H

  1. Author:
    Kim, J. A.
    Yang, S. Y.
    Wamiru, A.
    McMahon, J. B.
    Le Grice, S. F. J.
    Beutler, J. A.
    Kim, Y. H.

  2. Author Address

    [Kim, JA; Yang, SY; Kim, YH] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea [Wamiru, A; McMahon, JB; Beutler, JA; Kim, YH] NCI, Mol Targets Lab, Ctr Canc Res, Frederick, MD 21702 USA [Wamiru, A] NCI, SAIC Frederick, Ctr Canc Res, Frederick, MD 21702 USA [Le Grice, SFJ] NCI, HIV Drug Resistance Program, Ctr Canc Res, Frederick, MD 21702 USA;Kim, JA (reprint author), Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea;yhk@cnu.ac.kr
    1. Year: 2011
    2. Date: May
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 21
    2. 10
    3. Pages: 2840-2844
  4. Type of Article: Article
  5. ISSN: 0960-894X
  1. Abstract:

    Two new monoterpene glycosides, distyloside A-B (1-2), and a new megastigmane glucoside, iso-dihydrodendranthemoside A (3) were isolated from twigs and leaves of Distylium racemosum, along with five known phenolic compounds (4-8). The structures were established via spectroscopic techniques and chemical transformations, and the absolute stereochemistry of 3 was determined by Mosher's esterification. A homogeneous fluorescence resonance energy transfer (FRET) quenching assay was used to determine the inhibitory activity of isolates (1-8) on the ribonuclease H enzymes from HIV-1, 2, human, and Escherichia coli. Among them, 6 ''-O-galloylsalidroside (6) showed potent inhibitory effects with an IC(50) value of 3.5 mu M on HIV-2, and 1.7 mu M on human RNase H, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bmcl.2011.03.091
  3. View record in Web of Science®
  4. WOS: 000290024200009

Library Notes

  1. Fiscal Year: FY2010-2011
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