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Structure-activity relationships of ustiloxin analogues

  1. Author:
    Joullie, M. M.
    Berritt, S.
    Hamel, E.

  2. Author Address

    [Joullie, MM; Berritt, S] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA [Hamel, E] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Frederick, MD 21702 USA;Joullie, MM (reprint author), Univ Penn, Dept Chem, 231 S 34th St, Philadelphia, PA 19104 USA;mjoullie@sas.upenn.edu
    1. Year: 2011
    2. Date: Apr
  2. Journal: Tetrahedron Letters
    1. 52
    2. 17
    3. Pages: 2136-2139
  4. Type of Article: Article
  5. ISSN: 0040-4039
  1. Abstract:

    Four novel ustiloxin D analogues were synthesized focusing on the size of the macrocyclic core, the stereochemistry at the bridgehead ether, and the enantiomer of ustiloxin D. All four were subjected to biological evaluation testing the inhibition of tubulin polymerization. Only 2,2-dimethyl-ustiloxin D retained any activity. (C) 2011 Elsevier Ltd. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.tetlet.2010.11.165
  3. View record in Web of Science®
  4. WOS: 000290184700031

Library Notes

  1. Fiscal Year: FY2010-2011
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