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Peripheral Blood-Derived Cd34(+) Progenitor Cells - Cxc Chemokine Receptor 4 and Cc Chemokine Receptor 5 Expression and Infection By Hiv

  1. Author:
    Ruiz, M. E.
    Cicala, C.
    Arthos, J.
    Kinter, A.
    Catanzaro, A. T.
    Adelsberger, J.
    Holmes, K. L.
    Cohen, O. J.
    Fauci, A. S.

  2. Author Address

    Ruiz ME NIAID IMMUNOREGULAT LAB NIH BLDG 10 ROOM 6A23 10 CTR DR MSC 1576 BETHESDA, MD 20892 USA NIAID IMMUNOPATHOL LAB NIH BETHESDA, MD 20892 USA NCI FREDERICK CANC RES & DEV CTR SCI APPLICAT INT CORP NIH FREDERICK, MD 21702 USA
    1. Year: 1998
  2. Journal: Journal of Immunology
    1. 161
    2. 8
    3. Pages: 4169-4176
  4. Type of Article: Article
  1. Abstract:

    The present study demonstrates cell surface expression of both CXC chemokine receptor 4 (CXCR4) and CC chemokine receptor 5 (CCR5), major coreceptors for T cell-tropic and macrophage-tropic strains of HIV, respectively, on CD34(+) progenitor cells derived from the peripheral blood. CD34+ progenitor cells were susceptible to infection by diverse strains of HIV, and infection could be sustained for prolonged periods in vitro. HIV entry into CD34(+) progenitor cells could be modulated by soluble CD4, HIV gp120 third variable loop neutralizing mAb and the cognate ligands for the CXCR4 and CCR5 HIV coreceptors, This study suggests that a significant proportion of the circulating progenitor cell pool may serve as a reservoir for HIV that is capable of trafficking the virus to diverse anatomic compartments. Furthermore, the infection and ultimate destruction of these progenitor cells may explain in part the defective lymphopoiesis in certain HIV-infected individuals despite effective control of virus replication during highly active antiretroviral therapy. [References: 70]

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