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Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors

  1. Author:
    Jones, K. S.
    Lambert, S.
    Bouttier, M.
    Benit, L.
    Ruscetti, F. W.
    Hermine, O.
    Pique, C.

  2. Author Address

    [Lambert, S; Bouttier, M; Benit, L; Pique, C] Inst Cochin, INSERM, U1016, F-75014 Paris, France [Jones, KS] NCI Frederick, Basic Sci Program, SAIC Frederick Inc, Frederick, MD 21702 USA [Lambert, S; Bouttier, M; Benit, L; Pique, C] CNRS, UMR8104, F-75014 Paris, France [Lambert, S; Bouttier, M; Benit, L; Pique, C] Univ Paris 05, F-75006 Paris, France [Ruscetti, FW] NCI Frederick, Canc & Inflammat Program, Frederick, MD 21702 USA [Hermine, O] Hop Necker Enfants Malad, Serv Hematol Adulte, F-75743 Paris 15, France;Pique, C (reprint author), Inst Cochin, INSERM, U1016, 22 Rue Mechain, F-75014 Paris, France;joneska@mail.nih.gov s.lambert@inserm.fr manuella.bouttier@igmm.cnrs.fr laurence.benit@inserm.fr ruscettf@mail.nih.gov ohermine@gmail.com claudine.pique@inserm.fr
    1. Year: 2011
    2. Date: Jun
  2. Journal: Viruses-Basel
    1. 3
    2. 6
    3. Pages: 794-810
  4. Type of Article: Review
  5. ISSN: 1999-4915
  1. Abstract:

    The initial step in retroviral infection involves specific interactions between viral envelope proteins (Env) and specific receptors on the surface of target cells. For many years, little was known about the entry receptors for HTLV-1. During this time, however, functional domains of the HTLV-1 Env were identified by analyzing the effects of neutralizing antibodies and specific mutations in Env on HTLV-1 infectivity. More recent studies have revealed that HTLV-1 infectivity involves interactions with three different molecules: heparan sulfate proteoglycans (HSPG), the VEGF-165 receptor Neuropilin 1 (NRP-1) and glucose transporter type 1 (GLUT1). Here, we revisit previously published data on the functional domains of Env in regard to the recent knowledge acquired about this multi-receptor complex. We also discuss the similarities and differences between HTLV-1 and other deltaretroviruses in regards to receptor usage.

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External Sources

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  2. DOI: 10.3390/v3060794
  3. View record in Web of Science®
  4. WOS: 000292027700008

Library Notes

  1. Fiscal Year: FY2010-2011
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