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Lack of Compartmentalization of HIV-1 Quasispecies Between the Gut and Peripheral Blood Compartments

  1. Author:
    Imamichi, H.
    DeGray, G.
    Dewar, R. L.
    Mannon, P.
    Yao, M.
    Chairez, C.
    Sereti, I.
    Kovacs, J. A.

  2. Author Address

    [Imamichi, H; Chairez, C; Sereti, I] NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA [DeGray, G; Dewar, RL] NCI, Clin Serv Program, SAIC Frederick, Frederick, MD 21701 USA [Mannon, P; Yao, M] NIAID, Host Def Lab, Bethesda, MD 20892 USA [Kovacs, JA] NIH, Dept Crit Care Med, Ctr Clin, Bethesda, MD 20892 USA;Imamichi, H (reprint author), NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bldg 550,Room 201-A,POB B, Frederick, MD 21702 USA;himamichi@nih.gov
    1. Year: 2011
    2. Date: Jul
  2. Journal: Journal of Infectious Diseases
    1. 204
    2. 2
    3. Pages: 309-314
  4. Type of Article: Article
  5. ISSN: 1537-6613
  1. Abstract:

    Compartmental differences in human immunodeficiency virus type 1 (HIV-1) between the gut and peripheral blood and within the gut were examined. Biopsy specimens from the colon and ileum and peripheral blood samples were collected from chronically HIV-1-infected individuals. HIV-1 envelope sequences were examined from cell-associated DNA and RNA and virion RNA. Phylogenetic analysis revealed no evidence of compartmentalization of HIV-1 between the gut and peripheral blood and within the gut (colon and ileum). HIV-1 sequences detected in the gut were transcriptionally active and were also found in peripheral blood from matching time points, providing evidence of ongoing virus production in the gut and equilibrium of HIV-1 between the gut and peripheral blood compartments.

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External Sources

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  2. DOI: 10.1093/infdis/jir259
  3. View record in Web of Science®
  4. WOS: 000292562200021

Library Notes

  1. Fiscal Year: FY2010-2011
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