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Diverse interactions of retroviral Gag proteins with RNAs

  1. Author:
    Rein, A.
    Datta, S. A. K.
    Jones, C. P.
    Musier-Forsyth, K.

  2. Author Address

    [Rein, A; Datta, SAK] NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA [Jones, CP; Musier-Forsyth, K] Ohio State Univ, Dept Chem, Ctr Retroviral Res, Columbus, OH 43210 USA [Jones, CP; Musier-Forsyth, K] Ohio State Univ, Dept Biochem, Ctr Retroviral Res, Columbus, OH 43210 USA [Jones, CP; Musier-Forsyth, K] Ohio State Univ, Ctr RNA Biol, Columbus, OH 43210 USA;Rein, A (reprint author), NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA;reina@mail.nih.gov
    1. Year: 2011
    2. Date: Jul
  2. Journal: Trends in Biochemical Sciences
    1. 36
    2. 7
    3. Pages: 373-380
  4. Type of Article: Review
  5. ISSN: 0968-0004
  1. Abstract:

    Retrovirus particles are constructed from a single virus-encoded protein, termed Gag. Given that assembly is an essential step in the viral replication cycle, it is a potential target for antiviral therapy. However, such an approach has not yet been exploited because of the lack of fundamental knowledge concerning the structures and interactions responsible for assembly. Assembling an infectious particle entails a remarkably diverse array of interactions, both specific and nonspecific, between Gag proteins and RNAs. These interactions are essential for the construction of the particle, for packaging of the viral RNA into the particle, and for placement of the primer for viral DNA synthesis. Recent results have provided some new insights into each of these interactions. In the case of HIV-1 Gag, it is clear that more than one domain of the protein contributes to Gag RNA interaction.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.tibs.2011.04.001
  3. View record in Web of Science®
  4. WOS: 000292720900004

Library Notes

  1. Fiscal Year: FY2010-2011
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