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Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?

  1. Author:
    Reizis, B.
    Colonna, M.
    Trinchieri, G.
    Barrat, F.
    Gilliet, M.

  2. Author Address

    [Reizis, B] Columbia Univ, Dept Microbiol & Immunol, New York, NY 10032 USA [Colonna, M] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA [Trinchieri, G] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA [Barrat, F] Dynavax Technol Corp, Berkeley, CA 94710 USA [Gilliet, M] Univ Hosp Lausanne CHUV, Dept Dermatol, CH-1011 Lausanne, Switzerland;Reizis, B (reprint author), Columbia Univ, Dept Microbiol & Immunol, 701 W 168th St, New York, NY 10032 USA;bvr2101@columbia.edu mcolonna@pathology.wustl.edu trinchig@mail.nih.gov fbarrat@dynavax.com Michel.Gilliet@chuv.ch
    1. Year: 2011
    2. Date: Aug
  2. Journal: Nature Reviews Immunology
    1. 11
    2. 8
    3. Pages: 558-U82
  4. Type of Article: Article
  5. ISSN: 1474-1733
  1. Abstract:

    Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs - do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses?

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External Sources

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  2. DOI: 10.1038/nri3027
  3. View record in Web of Science®
  4. WOS: 000293069600015

Library Notes

  1. Fiscal Year: FY2010-2011
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