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Application of a water-soluble pyridyl disulfide amine linker for use in Cu-free click bioconjugation

  1. Author:
    Thomas, J. D.
    Burke, T. R.

  2. Author Address

    [Thomas, JD; Burke, TR] NCI, Biol Chem Lab, Mol Discovery Program, Ctr Canc Res,NIH, Frederick, MD 21702 USA;Burke, TR (reprint author), NCI, Biol Chem Lab, Mol Discovery Program, Ctr Canc Res,NIH, Frederick, MD 21702 USA;tburke@helix.nih.gov
    1. Year: 2011
    2. Date: Aug
  2. Journal: Tetrahedron Letters
    1. 52
    2. 33
    3. Pages: 4316-4319
  4. Type of Article: Article
  5. ISSN: 0040-4039
  1. Abstract:

    Described herein is the design and synthesis of a discrete heterobifunctional PEG-based pyridyl disulfide/amine-containing linker that can be used in the Cu-free click preparation of bioconjugates. The title PEG-based pyridyl disulfide amine linker is a potentially useful reagent for preparing water-soluble disulfide-linked cargos, and that it may be particularly valuable in expanding the field of Cu-free click-based bioconjugations to include reductively labile antibody, polymer, or nanoparticle-based drug conjugates. Published by Elsevier Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.tetlet.2011.06.042
  3. View record in Web of Science®
  4. WOS: 000293436100019

Library Notes

  1. Fiscal Year: FY2010-2011
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