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RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis

  1. Author:
    Lipkowitz, S.
    Weissman, A. M.

  2. Author Address

    [Lipkowitz, S] NCI, Cellular & Mol Biol Lab, Bethesda, MD 20892 USA. [Weissman, AM] NCI, Lab Prot Dynam & Signaling, Frederick, MD 21702 USA.;Lipkowitz, S (reprint author), NCI, Cellular & Mol Biol Lab, Bldg 37, Bethesda, MD 20892 USA;lipkowis@mail.nih.gov amw@nih.gov
    1. Year: 2011
    2. Date: Sep
  2. Journal: Nature Reviews Cancer
    1. 11
    2. 9
    3. Pages: 629-643
  4. Type of Article: Review
  5. ISSN: 1474-175X
  1. Abstract:

    The ubiquitin-proteasome system has numerous crucial roles in physiology and pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases (E3s). Of these, the majority are RING finger and RING finger-related E3s. Many RING finger E3s have roles in processes that are central to the maintenance of genomic integrity and cellular homeostasis, such as the anaphase promoting complex/cyclosome (APC/C), the SKP1-cullin 1-F-box protein (SCF) E3s, MDM2, BRCA1, Fanconi anaemia proteins, CBL proteins, von Hippel-Lindau tumour suppressor (VHL) and SIAH proteins. As a result, many RING finger E3s are implicated in either the suppression or the progression of cancer. This Review summarizes current knowledge in this area.

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External Sources

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  2. DOI: 10.1038/nrc3120
  3. View record in Web of Science®
  4. WOS: 000294203400011

Library Notes

  1. Fiscal Year: FY2011-2012
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