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Mechanisms and Factors that Influence High Frequency Retroviral Recombination

  1. Author:
    Delviks-Frankenberry, K.
    Galli, A.
    Nikolaitchik, O.
    Mens, H.
    Pathak, V. K.
    Hu, W. S.

  2. Author Address

    [Galli, A; Nikolaitchik, O; Hu, WS] NCI, Viral Recombinat Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA. [Delviks-Frankenberry, K; Pathak, VK] NCI, Viral Mutat Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA. [Galli, A] Copenhagen Univ Hosp, Dept Infect Dis, Copenhagen Hepatitis Program C, DK-2650 Hvidovre, Denmark. [Mens, H] Rigshosp, Dept Epidem Dis, DK-2100 Copenhagen, Denmark.;Hu, WS (reprint author), NCI, Viral Recombinat Sect, HIV Drug Resistance Program, Frederick, MD 21702 USA;frankenk@mail.nih.gov andrea.galli@hvh.regionh.dk nikolaio@mail.nih.gov helene.mens@gmail.com vinay.pathak@nih.gov wei-shau.hu@nih.gov
    1. Year: 2011
    2. Date: Sep
  2. Journal: Viruses-Basel
    1. 3
    2. 9
    3. Pages: 1650-1680
  4. Type of Article: Review
  5. ISSN: 1999-4915
  1. Abstract:

    With constantly changing environmental selection pressures, retroviruses rely upon recombination to reassort polymorphisms in their genomes and increase genetic diversity, which improves the chances for the survival of their population. Recombination occurs during DNA synthesis, whereby reverse transcriptase undergoes template switching events between the two copackaged RNAs, resulting in a viral recombinant with portions of the genetic information from each parental RNA. This review summarizes our current understanding of the factors and mechanisms influencing retroviral recombination, fidelity of the recombination process, and evaluates the subsequent viral diversity and fitness of the progeny recombinant. Specifically, the high mutation rates and high recombination frequencies of HIV-1 will be analyzed for their roles in influencing HIV-1 global diversity, as well as HIV-1 diagnosis, drug treatment, and vaccine development.

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External Sources

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  2. DOI: 10.3390/v3091650
  3. View record in Web of Science®
  4. WOS: 000295211400008

Library Notes

  1. Fiscal Year: FY2011-2012
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