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Synthesis and Anticancer Activity of 13-Membered Cyclic Enediynes

  1. Author:
    Sharma, M.
    Joshi, M. C.
    Kumar, V.
    Malhotra, S. V.
    Rawat, D. S.
  2. Author Address

    [Sharma, M; Joshi, MC; Rawat, DS] Univ Delhi, Dept Chem, Delhi 110007, India. [Kumar, V; Malhotra, SV] NCI, Lab Synthet Chem, SAIC, Frederick Inc, Frederick, MD 21701 USA.;Rawat, DS (reprint author), Univ Delhi, Dept Chem, Delhi 110007, India;dsrawat@chemistry.du.ac.in
    1. Year: 2011
    2. Date: Sep
  1. Journal: Archiv Der Pharmazie
    1. 344
    2. 9
    3. Pages: 564-571
  2. Type of Article: Article
  3. ISSN: 0365-6233
  1. Abstract:

    We herein describe the synthesis of 15 novel 13-membered cyclic enediyne derivatives using simple and straightforward approach. Representative examples were screened for their anticancer activities on 60 different human tumor cell lines representing various histologies viz. leukemia, melanoma, and cancers of lung, colon, kidney, ovary, breast, prostate, and central nervous system. The enediyne derivatives with halogen substitutions, especially fluorides were found to be active against most of the cell lines. The initial results indicates marginal to good inhibition for the growth of tumor cells for several cell lines, which shows the potential of these class of compound towards anticancer application.

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External Sources

  1. DOI: 10.1002/ardp.201000309
  2. WOS: 000295293800002

Library Notes

  1. Fiscal Year: FY2011-2012
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