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Resolving the identity myth: Key markers of functional CD4(+)FoxP3(+) regulatory T cells

  1. Author:
    Chen, X.
    Oppenheim, J. J.

  2. Author Address

    [Chen, X] NCI Frederick, BSP, SAIC Frederick Inc, Mol Immunoregulat Lab,CIP, Frederick, MD 21702 USA. [Oppenheim, JJ] NCI Frederick, Mol Immunoregulat Lab, Canc Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA.;Chen, X (reprint author), NCI Frederick, BSP, SAIC Frederick Inc, Mol Immunoregulat Lab,CIP, POB B,Bldg 560,Rm 31-19, Frederick, MD 21702 USA;chenxin@mail.nih.gov
    1. Year: 2011
    2. Date: Oct
  2. Journal: International Immunopharmacology
    1. 11
    2. 10
    3. Pages: 1489-1496
  4. Type of Article: Review
  5. ISSN: 1567-5769
  1. Abstract:

    Authenticating markers for the functional suppressive CD4(+)FoxP3(+) regulatory T cells (Tregs) are important for the quantitative identification and enrichment of viable Tregs for possible therapeutic use. CD25 as a surrogate marker of Tregs has some limitations, which prompted investigators to identify more specific marker(s) of Tregs. The search for a firm molecular definition of Tregs resulted in the identification of FoxP3 as a better marker of this subset of CD4 cells. Nevertheless, FoxP3(+) Tregs are phenotypically and functionally heterogeneous. Even in normal mice, only a minority of FoxP3(+) T cells are potent suppressor cells. Therefore, additional marker(s) are required for delineation of truly functional Tregs. In this review, the studies identifying markers of functional Tregs, both in mouse and in human, and their functional implications are discussed. Our finding that TNFR2, which mediates the effect of TNF on the activation of Tregs, is a superb marker of the most suppressive subset of mouse Tregs and its application in the identification of functional human Tregs will also be reviewed. (C) 2011 Elsevier B.V. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.intimp.2011.05.018
  3. View record in Web of Science®
  4. WOS: 000296000000012

Library Notes

  1. Fiscal Year: FY2011-2012
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