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Cationic liposomes are possible drug-delivery systems for HIV fusion inhibitor sifuvirtide

  1. Author:
    Franquelim, H. G.
    De-Sousa, F. F.
    Veiga, A. S.
    Santos, N. C.
    Castanho, M.

  2. Author Address

    [Franquelim, HG; De-Sousa, FF; Veiga, AS; Santos, NC; Castanho, MARB] Univ Lisbon, Fac Med, Inst Med Mol, P-1649028 Lisbon, Portugal. [Veiga, AS] NCI, Biol Chem Lab, Frederick, MD 21701 USA.;Castanho, MARB (reprint author), Univ Lisbon, Fac Med, Inst Med Mol, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal;macastanho@fm.ul.pt
    1. Year: 2011
    2. Date: Dec 7
  2. Journal: Soft Matter
    1. 7
    2. 23
    3. Pages: 11089-11092
  4. Type of Article: Article
  5. ISSN: 1744-683X
  1. Abstract:

    HIV-1 inhibitor sifuvirtide presents increased affinity for cationic dipalmitoylethyl-phosphatidylcholine (EDPPC) in contrast to viral/raft-mimicking (VRM) membranes. When associated to sifuvirtide, EDPPC-containing vesicles fuse with VRM vesicles. After fusion, the peptide co-localizes on VRM vesicles, indicating an effective delivery and concentration of sifuvirtide towards the viral and lipid raft vicinity.

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External Sources

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  2. DOI: 10.1039/c1sm06553j
  3. View record in Web of Science®
  4. WOS: 000297029500007

Library Notes

  1. Fiscal Year: FY2011-2012
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