Skip NavigationSkip to Content
Return Return to Search Results

Contrasting effects of TNF and anti-TNF on the activation of effector T cells and regulatory T cells in autoimmunity

  1. Author:
    Chen, X.
    Oppenheim, J. J.

  2. Author Address

    [Oppenheim, Joost J.] NCI, Mol Immunoregulat Lab, Ctr Canc Res, Frederick, MD 21702 USA. [Chen, Xin] NCI, Basic Sci Program, SAIC Frederick Inc, Mol Immunoregulat Lab, Frederick, MD 21702 USA.;Oppenheim, JJ (reprint author), NCI, Mol Immunoregulat Lab, Ctr Canc Res, Frederick, MD 21702 USA;oppenhej@mail.nih.gov
    1. Year: 2011
    2. Date: Dec
  2. Journal: Febs Letters
    1. 585
    2. 23
    3. Pages: 3611-3618
  4. Type of Article: Review
  5. ISSN: 0014-5793
  1. Abstract:

    Anti-TNF treatment is effective in a majority of rheumatoid arthritis (RA), however, this treatment can unexpectedly trigger the onset or exacerbate multiple sclerosis (MS). Recent progress in cellular immunology research provides a new framework to analyze the possible mechanism underlying these puzzling contradictory effects. The delicate balance of protective CD4(+)FoxP3(+) regulatory T cells (Tregs) and pathogenic CD4(+)FoxP3(-) effector T cells (Teffs) is crucial for the outcome of anti-TNF treatment of autoimmune disease. There is convincing evidence that TNF, in addition to stimulating Teffs, is able to activate and expand Tregs through TNFR2, which is preferentially expressed by Tregs. Therefore, the contrasting effects of TNF on Tregs and Teffs are likely to determine the therapeutic effect of anti-TNF treatment. In this review, we discuss the current understanding of the general effect of TNF on the activation of T cells, and the impact of TNF on the function of Teffs and Tregs. Understanding the differential effects of TNF on Teffs and Tregs is fundamentally required for the design of more effective and safer anti-TNF or anti-TNF receptor(s) therapeutic strategy for autoimmune diseases. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.febslet.2011.04.025
  3. PMID: 21513711
  4. View record in Web of Science®
  5. WOS: 000297318000003

Library Notes

  1. Fiscal Year: FY2011-2012
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel