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Hypoxia, stem cells and bone tumor

  1. Author:
    Zeng, W.
    Wan, R.
    Zheng, Y. H.
    Singh, S. R.
    Wei, Y. Y.

  2. Author Address

    [Singh, Shree Ram] NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA. [Zeng, Wen] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Orthopaed, Shanghai 200080, Peoples R China. [Zeng, Wen; Wan, Rong; Zheng, Yuehuan; Wei, Yiyong] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Orthopaed,Inst Traumatol & Orthopaed, Shanghai 200025, Peoples R China.;Singh, SR (reprint author), NCI, Mouse Canc Genet Program, NIH, Frederick, MD 21702 USA;singhshr@mail.nih.gov dr.yiyongwei@yahoo.com
    1. Year: 2011
    2. Date: Dec
  2. Journal: Cancer Letters
    1. 313
    2. 2
    3. Pages: 129-136
  4. Type of Article: Review
  5. ISSN: 0304-3835
  1. Abstract:

    Normal oxygen level is critical for niches that together with other components of the niche play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in normal development and disease progression, including the growth of solid tumors. The hypoxia inducible factors (HIFs) are the key mediators of the cellular response to hypoxia. In this review, we focused on the role of HIFs on bone tumor formation. Further, we also emphasized how hypoxia, stem cells, and its niches regulate the bone tumorigenesis. Published by Elsevier Ireland Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.canlet.2011.09.023
  3. View record in Web of Science®
  4. WOS: 000297895800002

Library Notes

  1. Fiscal Year: FY2011-2012
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