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Redundancy of C/Ebp-Alpha, -Beta, and -Delta in Supporting the Lipopolysaccharide-Induced Transcription of Il-6 and Monocyte Chemoattractant Protein-1

  1. Author:
    Hu, H. M.
    Baer, M.
    Williams, S. C.
    Johnson, P. F.
    Schwartz, R. C.
    1. Year: 1998
  2. Journal: Journal of Immunology
    1. 160
    2. 5
    3. Pages: 2334-2342
  4. Type of Article: Article
  1. Abstract:

    C/EBP alpha, -beta, and -delta are members of the CCAAT/enhancer binding protein family of transcriptional regulators. All three of these factors are expressed by bone marrow-derived macrophages, with the DNA binding activity of C/EBP beta and -delta increased by treatment with LPS while that of C/EBP alpha is decreased, We have ectopically expressed each C/EBP protein in P388 lymphoblasts, The expression of any of these transcription factors is sufficient to confer the LPS-inducible expression of IL-6 and monocyte chemoattractant protein-1 to lymphoblasts, which normally lack C/EBP factors and do not display LPS induction of proinflammatory cytokines, Thus, the activities of C/EBP alpha, -beta, and -delta are redundant in regard to the expression of IL-6 and monocyte chemoattractant protein-1. Since C/EBP beta-deficient mice have been reported to be largely normal in their expression of proinflammatory cytokines, it is likely that the lark of C/EBP beta is compensated for by the induction of C/EBP delta upon LPS treatment. [References: 37]

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